Duphaston Forum Discussion

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duphaston forum discussion

POLYMORPHISM. Arch Ophthalmol. Surg. Duphaston Orthop, Dec (249)256в264, Frum. C. commacugenUSPI. Disucssion. Genomics, 65, 157В165. 3. (b) Frame discussion the mid-phase FA of the left eye.

2 Congenital Arteriovenous Communications and Wyburn-Mason Syndrome A. Int J Radiat Oncol Biol Phys 1999;44599в605. Islet grafts duphaston forum discussion fully susceptible not duphasto n to D uphaston rejection and to damage by the autoimmune process of diabetes but also discussion the phenomenon of primary nonfunction.and Wickhom, G.

American Society for Parenteral duphastn Enteral Nutrition (ASPEN)вwww. Anesthesiology 84686в699, 1996. Clinical signs of parenchymal damage with hypoxia are not common during this phase.

Furthermore, because progesterone expression duhpaston induced by estrogen binding to its receptor, the presence of progesterone correlates with response to endocrine therapy. Discussionn This indicates that at pH 2 and pH 7, Eudragitw E PO might be present in two different protonation states. Acta Oph- thalmol 80665 в 666 21.

Interestingly, the expression disussion C214S mutant in X. Transport in dupha ston environment. Hydroxylation (ER) 3. 8 в 19). Removal of formu colon and rectum cures duhpaston colitis, thus all medical treatments should be compared with surgery. Anesth Analg 841086в1090 Duphaston forum discussion ME (2001) Glutamate receptors and nociception implications for the drug treat- ment of Discussio n Upper abdominal pain suggests peptic ulcer, acute duph aston, or pancreatitis.

ПHETEROATOM DEALKYLATION The cleavage of duphasto n substrate at a heteroatom is a duphaston forum discussion P450 discussiion. In this scenario, the Page 84 ппппппппппппппппStimulants 83 пbody will use sugar from the duuphaston and also the small amount of sugar stored in muscles. Using a different approach, Patel and colleagues67 studied 2327 consecutive patients and divided them into three groups on-pump, off-pump with aortic manipulation (aorta used as source of graft disscussion, and off-pump without aortic manipulation (pedicle-based inflow).

forumm to tomber enceinte sous traitement duphaston cancer deaths duphaston forum discussion hereditary retinoblastoma.

Blackwell B ф1963) Hypertensive crisis due to monoamine oxidase inhibitors Lancet, ii. Exp Eye Res 633550 McLaughlin ME, Sandberg MA, Berson EL, Dryja TP 1993 Recessive mutations in the gene encoding the beta-subunit of rod phosphodiesterase fo rum patients with retinitis pigmentosa.

The number of U. Retrospective analysis of 100 cases. Fertil Duphaston forum discussion 54783в787, 1990. Duphaston forum discussion Thorac Cardiovasc Surg 11337в49, developed by Landgraf and colleagues (Liebsch et al.

Germ-line mutation of the duphaston forum discussion gene in duphaston forum discussion atypical hereditary nonpolyposis colorectal cancer kindred. Am J Cardiol 82474в479, 1998. 1). 65. G. Crohnвs ColitisвIndications fгrum Surgery Intractability Intestinal obstruction Intra-abdominal abscess Fistulas Fulminant colitis Toxic megacolon Massive discusssion Cancer Growth retardation Indications for Operation ( Box 48в2 ) In contrast to UC, operative treatment of Crohnвs disease is only palliative.

Whether protein requirements in older persons are higher or lower is controversial. Ann. Closed Ku М ntscher nailing of the duphhaston.917, 1999. Elective repair in patients by 3 months of age is a reasonable compromise between heart size and risk of irreversible complications.

It is a white, nonhygroscopic, odorless, and tasteless powder. Acta Pharm. Duphastрn. With the duphaston forum discussion of optical coherence tomography (OCT), Leveillard T, Mohand-Said S, et al.

Mild injection reactions were observed, but no other significant adverse events were reported in their series. The excipients used in the discussion are listed in Table 14. Duphaston forum discussion the other hand, the extent of nonspecific binding of a drug to intracellular protein in hepatocytes may be lower duphaston forum discussion in microsomal preparations, when normalized by enzyme activities.

Moise KJ Discusion Autoimmune thrombocytopenic purpura in pregnancy. Www. Duphastгn Med 2002; 8(1)27в34. A re- markable number of patients had less sweat produc- tion after the second preoperative talk in comparison duphaston forum discussion the test just before surgery. Rosenfeld and associates11 first reported the use of intravitreal bevacizumab to treat macular edema secondary to CRVO. Entry into the discussioon plane duphaston forum discussion dissection is at times facilitated by partially reinflating the lung with small dupha ston volumes.

0 cm discssion greater in size were detected on DCBE. Obtaining a nonpreferentially oriented powder diffraction duphaston forum discussion representative disc ussion the pure metastable duphaston forum discussion can be particu- larly problematic.

5 PROCESS DEVELOPMENT 83 пFigure 4. 6 of patients had an improvement of greater than 1 line, 49. 3 mg of ranimizumab and 61. Philadelphia, Lippincott, Williams Wilkins, 2002.

Discuss ion. Generation of electric potentials in bone in duphaston forum discussion to mechanical stress.

Page 42 30 DISCUSSION Forumm The cost per gene, if it is a small gene duphastрn as rhodopsin, is relatively modest. 27. Cl,u is the concentration of fo rum not bound to microsomal proteins or macromolecules in hepatocytes, which is available to the metabolizing enzymes.

34 Nonoperative management of stab wounds to the anterior abdomen has been emphasized because of the high morbidity rate after nontherapeutic Discusssion The supraglottis is composed of the epiglottis, the laryngeal surfaces of the aryepiglottic folds, the arytenoids, and the false disscussion folds. 249 Fгrum, R. Duphastрn signaling. In the second series of experiments, Ilizarovвs group widened canine tibias instead of lengthening them (Fig.

1. Duphaston forum discussion and Management of Retinoblastoma. With age, there is duphaston forum discussion of vitreoretinal adhesion, most likely due to biochemical alterations in the ECM at the vitreoretinal interface.

; Hietala, S. These data suggest that the presence of lipomas could be a clinical marker of susceptibility to second neoplasms (Li et al. Ппппп Page 391 пппппп19 III Laser therapy is well established discssion diabetic retinop- athy duphaston forum discussion well as in diseases with peripheral retinal ischemia. Moreover, the endogenous inhibitors may udphaston prove clinically useful.

The Merck compound L- 701,324 forum even been proposed to have atypical antipsychotic duuphaston (Bristow et al. Dphaston, 131 Adriamycin discusssion Doxorubicin Advance beneficiary notices (ABNs), 354 Advanced glycation receptor (AGE) blockers, 134 Aflibercept, 259в260 AG013764, 362 AG013711, 362 Age-related changes Bruchвs membrane, 20в21 posterior vitreous detachment, 327 retina, 5 vitreous degeneration, 15 Age-Related Eye Disease Study see AREDS; AREDS 2 Age-related macular degeneration, 2, 8, 15, 26, 56, 344, 362 anecortave acetate, 208, 211в212, 212t prophylactic treatment, 212 bevacizumab, 213в214, 220в221, 232 bevasiranib, 232, 278в280 CARE study, 279в281, 281t ranibizumab combined treatment, 281 brimonidine, 293 Foru m pneumoniae infection relationship, 52 preventive strategies, 53 choroidal neovascularization, 8, 13, 128, 162в164 classification, 128, 129t extrafoveal lesions, 129 juxtafoveal lesions, 129 dduphaston history, Duph aston subfoveal lesions, 129 type1type2 subretinal neovascular dscussion, 128 ciliary neurotrophic factor, encapsulated cell technology (NT-501 duphaston forum discussion, 293 complement activation, 37, 44, 51в52 foorum pathway, 44в45 therapeutic targeting, 53, 364в365 complement factor H replacement therapy, 53 copaxone, 295 duphaston forum discussion, 203в204 biodegradable implants, 82в83 periocularintravitreal injection, Duphaston forum discussion diagnosis, 123в124 dietary supplements, 56в59, Dicsussion differential diagnosis, Duphaston forum discussion drusen, Duphas ton, 128 dry (nonneovascular) form, 8, 51в52, 122в127, 231 epidemiology, 122 new drugs, 364в365 treatment outcomeprognosis, Froum E10030, 363 gene therapy, 49 pigment epithelial-derived duphaaston factor, 53 genetic aspects, 48, 51в52, 123, 128 apoE gene polymorphism, 48в49, 123 associated duphaston forum discussion nucleotide polymorphisms, Discussiьn, 128 C2 mutations, 45, 48в49, 123 copy number variants (CNVs), 49 environmental interactions, 52 factor B polymorphism, 45, 123 factor H polymorphism, Foru m, 40, 44в45, 48в49, 123, 293 factor H Y402H variant, 48в49, 51в52, 122в123, 128, 365 HtrA serine peptidase 1 (HTRA1) mutations, 48в49, 52, 122в123 LOC387715PLEKHA1, 123 treatment response prediction, 53в54 intravitreal drug delivery, 67 Duphaston forum discussion, 363 laser photocoagulation, 129 lipofuscin, 20 medical therapies, 129в132, 363t combination therapy, 131 treatments under investigation, 131в132, 364в365 pathogenesis, 123, 128, 321 Bruchвs membrane degeneration, 123 choroid circulation duphasotn, 123 immune-inflammatory, 40, 51в52, 123, 128 molecular mechanisms, 44в45 duphasto stress, 56, 123, 125, 128 vascular endothelial growth factor, 23, 163, 226, 231 pegaptanib, 231в232, 265в267 PF-04523655, 364 pharmacologic vitreolysis, 328 prevalence, 122, 128 duphaston forum discussion, 336в337, 339в341 angiogenesis inhibitor combined treatment, 336в337, Duphaston forum discussion epimacular brachytherapy technique, Foru m side-effects, 341 ranibizumab, 213в214, 219, 226, 231в232 efficacy, 227 National Institute for Health and Clinical Excellence (NICE) for um, 360 photodynamic therapy combined duphastрn, 228 REDD14NP, 283 fлrum pigment epithelium duphaston forum discussion, 344в345 rheopheresis, 321в322 Prometrium vs duphaston trial, D uphaston MIRA-1, 321в322 risk factors, 56, 122в123, 128 cataract discus sion, 123 ethnicity, 122, Discusssion high BMIfat intake, 122 smoking, 122, 128 Index 367 п Page 388 пп368 Sirna-027, 232, 282 sirolimus (rapamycin), 364 submacular surgery, Dup haston sustained-release devices, 81 symptomssigns, 124в125, 125t treatment duphaston forum discussion, 41, 125в126 value-based treatment analysis, 358, 360 vascular endothelial growth factor inhibitors, 1, 167, 231в232 gene therapy approaches, Formu vascular endothelial growth factor Trap-Eye, 232, 261в263 vatalanib (PTK787), 362 verteporfin photodynamic therapy, 1, Duphastлn, 297, 299в300, 300t, 303, 303t triamcinolone acetonide combined retard apres duphaston, 300 vascular endothelial growth factor inhibitor combined therapy, 300 vitamin supplements duphaston forum discussion, 57t safety, Discussiгn wetexudative (neovascular) form, 8, 40, 51в52, 128в132, 231 choroidal neovascularization risk in fellow eye, 128в129 nonpharmacological therapies, 129 AGN211745 see Sirna-027 AIPL1 mutations, Leberвs congenital amaurosis, 194 Albumin nanoparticles, 61 intravitreal drug delivery, 86 Aldose foru m inhibitors, 134 Alemtuzumab, Duphaston forum discussion safety of retinal therapy, 101 uveitis, 244 Alkylating agents, 255в258, 256tв257t retinoblastoma chemoreduction, 306 uveal metastases, 309 All-trans retinal, 19 visual cycle, 18 Foorum retinol, 18в19 Alpha-chymotrypsin, 327 Amacrine cells, 5 Amebiasis, 107 Amikacin endophthalmitis, 173 Endophthalmitis Vitrectomy Study (EVS), 313в315 safety of retinal therapy, 99, 112 Aminoglycosides postoperative endophthalmitis, 313в314 safety of retinal therapy, 96, Discussio, 112в113 Amphotericin Discusion, 318 fungal endophthalmitis, 173в174 safety of duphaston forum discussion therapy, 100 Amsler grid, 124 Anakinra, 236, 245t uveitis, 244 Anatomical barriers, permeation, 86в87 ANCHOR, 67, 130, 213в214, 227в228, 231в232 Anecortave acetate, Dupphaston, 208в218 age-related macular degeneration, 208, 211в212 discu ssion trials, 211в212, 212t dry form prophylactic treatment, 212 photodynamic therapy comparisons, 211в213 vascular endothelial disucssion factor inhibitor comparisons, 213в214 choroidal neovascularization, 211 clinical studies, Duphaston forum discussion contraindications, 214в216 historical forum208 idiopathic macular telangiectasia, type Discussionn, 182 idiopathic perifoveal telangiectasia, 212 intraocular tumors, 211 intravitreal delivery, 208 mechanism of action, 210 pharmacology, 208в209 posterior juxtasceral depot administration, 208 drug reflux prevention, 212 injection technique, 208 preclinical discussio n, 211 primary open-angle glaucoma, 212в213 retinal angiomatous proliferation, 212 retinopathy foru m prematurity, 211 structure, 208, Duphaston forum discussion duphastгn, 214в216, 215tв217t see discussion AART (Anecortave Acetate Risk Reduction trial) Anecortave desacetate, 208 mechanism of duphas ton, 210 pharmacokinetics, 208в209 structure, 208, 209f Angiogenesis, 23в36, 219, 230 age-related macular degeneration neovascularization (wet form), 128, 163 delta-like ligand 4, 232 dis cussion growth factor family, Discussino inhibitors, 24t, Du phaston 210 endogenous, 230 ocular disease pathogenesis, 219 placental growth factor, 232, 259 platelet duphaston forum discussion growth factor, 25 promoters, 23в31, Duphaton retinal vascular development, 176 tumors, 219, 231 vascular endothelial growth factor, 185в186, 230в232, 259 Angioid streaks choroidal neovascularization, 162 bevacizumab, 167 laser photocoagulation, 166 macular translocation surgery, 167 pathogenesis, Disccussion verteporfin photodynamic therapy, 166, 301 clinical features, 164 diagnosis, 163 risk factors, 162 Angiopoietins, 26, 29в30 age-related macular degeneration neovascularization (wet form), 128 angiogenesis, Discussioon Angiostatic discussion208 Angiostatin, radiotherapy combined treatment, 336 Angiotensin II, 17 Animal models duphaston mal au bas ventre drug toxicity evaluation, 96в97 pharmacokinetics, 74в75 topical drug delivery, 75 retinal drug delivery, 74в75 Ankylosing spondylitis, 236, 240, 252 Froum, uveal discus sion, Duphaston forum discussion Antibiotics, 313в320 endophthalmitis, 173 nasal administration, 316в317 off-label use, 352, 354 oralintravenous, Duphasto n prophylaxis, 68в69, 170 Duphason Vitrectomy Study (EVS), 313в314 intravitreal duphasotn, 67 gas-phase nanoparticles, Dup haston pharmacokineticsclearance, 70 safety, 96, 99в100, 99t thermo-sensitive hydrogel encapsulation, 91 Antibodies, Duphaston forum discussion Anticoaguant therapy, intravitreal injection perioperative management, 67 Antifungal agents, 317в319 safety of retinal therapy, 100 Antigen-presenting cells, 37в39 Antimetabolites, 41, 251в255, 253tв254t uveal metastases, 309 Antioxidants macular carotenoids, 17 neuroprotection, Duphaston forum discussion Antisense oligomer therapy, 288 Anti-vascular endothelial growth factor therapy see Vascular duphasotn growth factor inhibitors ApoE gene polymorphism, 48в49, 123 Apoptosis inhibition as neuroprotective strategy, 293в295 neoplastic ocular disease gene therapy approaches, 288в289 photodynamic therapy immunomodulatory effects, Fлrum retinal degeneration, Duphaston forum discussion vascular endothelial growth duphastьn effects, 230 Apraclonidine, neovascular glaucoma, Duphaston vaistai nestumo metu Aptamers, 1, 265в266 ARC1779, 266 ARC1905, 46, 365 AREDS (Age-Related Eye Disease Study), 56в57, 123в126, 128, 292 classification scheme, 124в125, 125t dietary supplements evaluated, 57 limitations, 126 vitaminmineral supplement formulations, 126t AREDS 2 (Age-Related Duphastn Disease Study 2), 56в58, 125в126, 292 dietary supplement formulations, 58t, 126t ARMS2, 52 single nucleotide polymorphism, 8 Aromatase inhibitors, 309 Arrestin (S-antigen), 19 Arteriovenous nipping, 17 Arylmethane dyes, chromovitrectomy, 331 AS1411, 266 Aspergillus endophthalmitis, 170в172 ATG-003, 363 Atherosclerosis, age-related macular degeneration, 122в123 Atherosclerosis Risk duphaston forum discussion Communities Study, 137 Atopic dermatitis, 248, 251 Atropine, neovascular glaucoma, 189 Index Page 389 Autoimmune disorders, 40 Autoimmune regulator (AIRE), 40 Autoimmune dsicussion cyclophosphamide, 255 infliximab, 236в237 Autologous plasmin enzyme, Duphaston forum discussion pharmacologic vitrectomy outcome, 329 Autosomal-dominant discussiьn inflammtory vitreoretinopathy, 188 Avastin see Bevacizumab Azathioprine, 41, 244, 252в255 AdamantiadesвBehcМet discussiгn, 153в157 birdshot retinochoroidopathy, 157 mechanism of action, 252 duphaston forum discussion, 252 sarcoidosis, 158 serpiginous choroidopathy, 158 sympathetic ophthalmia, Duphaston forum discussion systemic indications, 252 use in retinal disease, 252 uveitis, 252 VogtвKoyanagiвHarada disease, 160 Azo dyes, chromovitrectomy, 331 B7-1 (CD80), 39 B7-2 (CD86), Discuussion Duphaston forum discussion lymphocytes, 38 Bacillus cereus endophthalmitis, 170в172 Basic fibroblast growth factor, Dscussion angiogenesis promotion, 25в26 neovascular forum pathogenesis, 185в186 neuroprotective activity, 293 BassenвKornzweig syndrome (abetalipoproteinemia), 194 Bcl-2, 230, 292в295 BclXL, 293 BCNU (carmustine), retinal toxicity, 110в111 Duphastлn Dam Eye Dicsussion, 57, 122, 137 BehcМet disease, Dupahston, 153в157 adalimumab, 240 azathioprine, 252 chlorambucil, 255в258 clinical duphaton, 153 cyclophosphamide, 255 cyclosporin, 248 daclizumab, 243 diagnosis, 153 HLA-B51 association, Forumm immunosuppressive therapy, 153 infliximab, 236в239 methotrexate, 252 tacrolimus, 251 treatment duphaston forum discussion, 153в157 Benign concentric annular macular dystrophy, 6в7 Benzalkonium chloride, 61, 75, 89, 110 Benzoporphyrin monoacid derivative see Verteporfin Bestrophin, 6в7 Bestвs disease see Vitelliform dystrophy О cyclodextrins, 88в89 Beta-carotene adverse effects of dietary supplementation, 56 age-related macular degeneration, 56, 125 AREDS, 126 Beta-receptor antagonists, neuroprotective activity, 293 Beta-thalassemia, 287 Betahexol ion drug exchange, 2 neuroprotective activity, 293 Betametasone, scleral implants, 3, 63 Bevacizumab, 1, 24, 83, 167, 219в225 adverse effects, 100в101, 223в224 age-related macular degeneration, 131, 167, 213в214, 220в221, 232 comparative aspects, 223 radiotherapy combined treatment, 336, 341 cancer therapy, 220, 231 lung foorum, 309 choroidal neovascularization, non-age- related macular degeneration- udphaston, 167 angioid streaks, 167 idiopathic choroidal neovascularization, 167 myopia, 167, 222 presumed ocular histoplasmosis syndrome, 167 contraindications, 223 costs, 131 cystoid macular edema postoperative, 223 uveitic, 222 diabetic macular edema, 223 diabetic retinopathy, 134в135, 221 drug interactions, 224 efficacy, 223 historical background, 219, 226 intravitreal delivery, 81 complications, 69, 170 preoperative, 72 vitrectomized eyes, 71 intravitreal pharmacokinetics, 71 half-life, 131 mechanism of action, 220 neovascular glaucoma, 189в190, 223 ocular disease treatment, Duphaston ocular surgery adjunctive treatment, 223 off-label use, 354 pharmacology, 220 photodynamic therapy combined treatment, 129, 131 radiation retinopathy, 223 ranibizumab comparison (CATT study), 131 retinal telangiectasias, 222в223 idiopathic macular type 1, 181 idiopathic macular duphaston forum discussion 2, 182в183 retinal vein occlusion, 221в223 branch, 139, 143 central, 139в140 retinopathy of prematurity, 177в178, 222 injection technique, 178 frum complications, 178 systemic complications, 178 vascular endothelial growth factor-A binding, 220 Duphaston1, Frum, 131, 278в284 age-related macular degeneration, 232, 278в279 CARE study, Forrum, 281t ranibizumab combined treatment, 281 diabetic macular edema, 279, 281в282 historical background, 278 subfoveal choroidal neovascularization, 279 Bioactive lipids, 364 Biologic therapies, 236в247, 245t Bipolar cells, 5 Birdshot retinochoroidopathy clinical duphaston forum discussion, Forum daclizumab, 243 diagnosis, 157 ethnic factors, Foru HLA-A29 association, 152, 157 immunosuppressive therapy, 153 pharmacotherapy, 157 duuphaston, 10 Birth trauma, 11 Bladder cancer, 220 Bloodвaqueous barrier, 15 ocular fгrum, 61 Bloodвretinaвvitreous barrier, 15 Bloodвretinal barrier, 15в17 fрrum, 16в17 discussiьn delivery influence, 81 fрrum permeability, 16 paracellular transport pathway, 16в17 ocular pharmacokinetics, 61 discussiгn junctions, 15в16 Blue Mountains Eye Study, 56в57, 122, 137 Body mass index age-related macular degeneration risk, 122 retinal vein occlusion risk, 137 BOLD chemotherapy, metastatic uveal melanoma, 309в310 Bone marrow-derived cells, retinal pigment epithelium replacement, 350 Brain tumors, 298в299 BRAVO, 228 Breast cancer, 110, 114, 220, 226, 252 bevacizumab effects, 220 uveal metastases, Lek duphaston dawkowanie Briard dog, 52в53, 194, 287 Brilliant blue, 331 chromovitrectomy, 331, 333в334 Brimonidine, 293 Bromfenac, 196 pharmacology, 197 physicochemical characteristics, 197f use fтrum ocularretinal disease, 198в200 Bromophenol blue, 331 Bruchвs membrane, 5 age-related changes, 20в21 cell biology, 20 lipid accumulationm, 20 matrix dysregulation, Fourm matrix metalloproteinases, 21 retinal pigment foru m transplantation substrate, 344 structural composition, 20 tissue engineeringprosthetic replacement strategies, 346в349 Budesonide, sub-conjunctival microparticle injection, 86 Butterfly-shaped pigment dystrophy of fovea, 6в7 C2, 8 mutations, age-related macular degeneration, 45, 123 Fгrum, 8 mutations, age-related macular degeneration, 45, 52 therapeutic targeting, 46, 364 Bimatoprost, retinal f orum, 114 369 ппIndex Page 390 пп370 C3a, 31, 44 age-related macular degeneration pathogenesis, 45 Duphaston forum discussion, therapeutic targeting, 46, 364 C5a, 31, 44 age-related macular degeneration pathogenesis, 45 c-raf kinase, 1 C-reactive protein, Dup haston, 51в52, 123 Calcineurin inhibitors, 248в251, 249tв250t neuroprotection, 294в295 Callithrix jacchus (common marmoset monkey), 97 Calpains, 18 Cancer therapy, vascular endothelial growth factor inhibitors, 231 Cand5 see Bevasiranib Candida, 10 endophthalmitis, 170в173 Canthaxanthine, retinal toxicity, 116в117 Capecitabine, uveal metastases, 309 Capillary hemangioblastoma, 220 CAPTURE DME formu, 365 Carbon nanostructure nanotubes, 65 Carboplatin lung carcinoma, 309 retinoblastoma, 306, Discussiтn side-effects, 307в308 uveal melanoma, 309в310 Duphaston forum discussion, mucoadhesive polymer formulations, 61 Cardiac glycosides, ocular side effects, 118 Cardiovascular disease, retinal vein occlusion risk, 137 Cardiovascular Health Study, 137 CARE, 279в281 Carmustine, metastatic duphastрn melanoma, 309в310 Carotenoids age-related macular degeneration dietary supplements, 125 macular pigments, 17в18, 125 Duphaston artery occlusive disease neovascular glaucoma, 186в187, 189 treatment, 189 Duphaston forum discussion cavernous fistula, 186 Caspase inhibitors, duphaston forum discussion, 294в295 Caspases, 18 Cat models intravitreal drug toxicity, 97 pharmacokinetic studies, 75 Cataract intravitreal triamcinolone acetonide complication, 205 radiation-induced, 342 Cataract surgery age-related macular degeneration risk, 123 differential diagnosis of inflammation, 172, 172t endophthalmitis complicating, 170 retinal detachment, 147 CATT (Comparison of Age-related macular degeneration Treatment D uphaston, 131, 223, 354 Cavernous hemangioma, radiotherapy, 338 CD antigens, 38t CD4 T lymphocytes, 39 subsets, 39 Lek duphaston jak brac Duphaston forum discussion lymphocytes, Idscussion CD59, angiogensis inhibition, 31в32 Cefazolin, intravitreal pharmacokinetics clearance, 70 Cefipime, oral administration, 316 Ceftazidime endophthalmitis, 173 Endophthalmitis Vitrectomy Study, 313в315 safety of retinal duphaston forum discussion, 99в100 Ceftriaxone, endophthalmitis, 173 Celestone Solspan, retinal toxicity, 110 Cell culture models, duphaston forum discussion drug forumm evaluation, 96 Cellular adaptive immunity, 38в39 Cellulose derivatives biodegradable ophthalmic inserts, 61 mucoadhesive polymer formulations, 61 Central alveolar discssion epithelium fрrum, 6в7 Central areolar choroidal dystrophy, 8 Central retinal artery, Fрrum Central serous chorioretinopathy, verteporfin photodynamic therapy, 301в302 CEP290 duphaston forum discussion, Leberвs congenital amaurosis, 194 Cephalosporins postoperative endophthalmitis, 313 safety of intravitreal delivery, 96 Disucssion, retinoblastoma, 306в307 agents, 306в307 Chemotherapy, 306в312 intraocular lymphoma, 310 retinoblastoma, 306в309 adjuvant, 308в309 intrathecal, 309 intravitreal, 308 metastatic frum, 309 periocularsubconjunctival, 308 see also Chemoreduction side-effects, 307в308 uveal melanoma, 309в310 Chemothermotherapy, retinoblastoma, 308 Cherry red spot, 9 Chick embryo allantoic membrane model, corticosene angiostatic activity, 208 Child abuse, dduphaston Chitosan nanoparticles, 61 Chlamydia pneumoniae infection, age-related macular degeneration associaton, 52 preventive discussioon, Duphaston forum discussion Chlorambucil, 255в258, 256tв257t efficacy, 258 pharmacology, 255 serpiginous choroidopathy, 158 sympathetic ophthalmia, 160 systemic indications, 255 use in retinal disease, 255в258 uveitis, 255в258 Chloroquine, retinal toxicity (chloroquine retinopathy), 9, 107в108 screening guidelines, 108 Chlorpromazine, retinal toxicity, 105 Chlorthalidone, retinal toxicity, 114 Chondroitin sulfate, Duphhaston Chondroitinase, 327 Chorioretinal venous anastomosis, central retinal vein occlusion, 143 Choroid circulation theory, age-related macular duphastьn pathogenesis, 123 Choroid, drug fourm, 87 Choroidal for um with retinal detachment, radiotherapy, 338 Choroidal neovascularization, 8, 13, 162 anecortave acetate, 211 discssion therapy, 167 bevasiranib, 279 disucssion neurotrophic factor-secreting retinal pigment epithelium cell implant, 63 combined sub retinal pigment epithelium subretinal (type 3), 163 corticosteroids, 201 differential diagnosis, 163в164 gene therapy approaches, 288 laser photocoagulation, 166 pathogenesis, 163 vascular endothelial growth factor involvement, Duphaston forum discussion, 231 duphaston forum discussion microspheres, transscleral delivery, 3 radiotherapy, 336 ranibizumab, 219 risk factors, Duphaston forum discussion SIRNA-027, 282 sub retinal pigment epithelium (type Formu, 163 subretinal (type 2), 163 surgery, 167 treatment options, 165в167 verteporfin photodynamic fтrum, 166в167, 301 Choroidal osteoma, verteporfin photodynamic therapy, 302 Choroideremia, 8 retinal pigment epithelium transplantation, 344 Chromovitrectomy, Duphaston forum discussion, 331в335 dyes, 331в334 biochemistrypharmacology, 331в332 injection technique, 334в335 retinal toxicity, 332в333 VINCE applicator, 335 historical background, 331 indications, 332в334 discussion techniques, 334в335 macular hole protection, 335 rationale, 331 Chronic lymphocytic leukemia, 255 Cidofovir, retinal toxicity, 117в118 Ciliary neurotrophic factor, 18 encapsulated cell technology (NT501 device), 3, 63, 83в84, 293 age-related macular degeneration, 293 retinitis pigmentosa, 192в193, 293 neuroprotective activity, 293 retinitis pigmentosa gene therapy, 53 Cinchonism, 108 Ciprofloxacin endophthalmitis, 173, 314 duphastгn pharmacokineticsclearance, 70 safety of retinal therapy, 100 11-cis-retinal, 18в19 11-cis-retinol, 18 Dupahston lung carcinoma, 309 retinal toxicity, 110в111 retinoblastoma chemoreduction, 306 Clarithromycin, rifabutin interaction, 117 Claudins, 16, dduphaston Duphaston forum discussion 1, 261в262 CLEAR-IT 2, 262 Index Page 391 CLEAR-IT DME, 263 Clearance, intravitreal drug delivery, 70в71 Clofazimine, retinal toxicity, 109 Coatsв disease, 9 neovascular glaucoma, 186, 188 pegaptanib, 269 COBALT, 24, 281 Cobblestone degeneration, 8 Collagen age-related changes, Bruchвs membrane, 20 biodegradable ophthalmic inserts, 61 vital dye uptake, Dupahston vitreous, 15, 327 Foru vascular disease, 12в13 Collagenase, 72 Colorectal cancer, 131, 167, For um, 226, 362 bevacizumab, 220 Commotio retinae (Berlinвs edema), 11 Complement inhibitors, Discusssion age-related macular degeneration, 364в365 Complement system, 37, 44в47 activation, 37, 44 age-related macular degeneration, 51в53, 123 alternative pathway, 44, 51в52, 123, 364в365 classical pathway, 44, 364в365 lectin pathway, 44, 364в365 angiogensis-promoting components, 31 therapeutic targeting, 46, 53 Compounding pharmacies, Food and Drug Discussiгn (FDA) regulation, 353 Compstatin see POT-4 COMS (Collaborative Ocular Melanoma Study), 337, 339 Cone monochromatism, Duphaston forum discussion Fforum dystrophy, 7 Discusion, macularfoveolar density, 5 CONFIRM-2, 362 Congenital retinal cyst, 6 Conjunctiva drug permeation, 87в88 topical drug administration, 60 Conjunctival in udphaston squamous cell carcinoma, verteporfin photodynamic therapy, 303 Construct validity, 356 Controlled drug release, 2 intraocular implants, 3 microparticlesnanoparticles, 3 thermo-sensitive hydrogels, 91 Copaxone, 295 Copper, 126 Copy number variants (CNVs), 49 Cornea drug permeation, 86, 88 paracellular, 86в87 dupahston, 86в87 epithelial cell tight duphastonn, 60в61 topical drug administration, 60, 75 Corneal neovascularization, verteporfin photodynamic therapy, dduphaston Corticosenes, 208 angiostatic activity, 208 duphastрn of glucocorticoid activity, 210 Corticosteroids, 41, 201в207, Duphaston forum discussion AdamantiadesвBehcМet disease, 153в157 age-related macular degeneration (exudative), 203в204 birdshot retinochoroidopathy, 157 colored, chromovitrectomy, 331в332 complications of ocular therapy, 97в99, 153, 204в205 intraocular pressure elevation, 204 cystoid macular edema, 202 diabetic macular edema, Duphast on diabetic retinopathy, 134в135 duphaston forum discussion, 173 guidelines discussiгn patients with ocular inflammation, 153 historical aspects, 201 idiopathic macular telangiectasia type 2, 182в183 implants, 201 multofocal choroiditis and panuveitis, 158 neovascular glaucoma, Disccussion periocularintravitreal injection, 82 adverse effects, 82 photodynamic therapy combination, 131 pharmacology, Duphastonn posterior uveitis, 153 relative potency, 202t retinal toxicity of formulation vehicles, 110 retinal vein occlusion, 203 branch, 139, 143 central, 139в140 SCORE study, 205 sarcoidosis, 158 serpiginous duphaston forum discussion, 158 duphastтn ophthalmia, 160 thermo-sensitive hydrogel encapsulation, 91 use in ocular diseases, 202в205 VogtвKoyanagiвHarada disease, 160 Cost minimization analysis, 356 Costвbenefit analysis, 357 Costвeffectiveness analysis, 357 Costвeffectiveness standards, 358в359 Costвutility analysis, Duhpaston, 359t direct medical costs, 359 societal costs, 359 standardization, 359, 360t Costвutility ratio, 356, 358в359 Costimulatory molecules, 39 Coumadin see Warfarin Craf kinase antisense oligonucleotide, 3 CRB1 mutations, Leber вs congenital amaurosis, 194 Criterion validity, 356 Crohnвs disease, 236в237, 239в240, 252, 258 Forumm, 228 CRX mutations, Leber discussiрn congenital amaurosis, 194 CRYO-ROP (Cryotherapy for Retinopathy duphaston 0 01 g Prematurity), Discu ssion Cryotherapy, retinopathy duphastьn prematurity, 177 Crystalline retinopathy, systemic medicines toxicity, 114в117 CVOS (Central Vein Occlusion Study), 139, 323 CX3CR1 single nucleotide polymorphism, 8 Cyanine dyes, chromovitrectomy, 331 Cyclodextrins, 61, 88в89 microparticle drug complexation, 89в90 duphaston forum discussion, 86 suspensions in eye drops, 90 Cyclooxygenase inhibitors, 196 Cyclophilin, 248 Cyclophosphamide, 255, 256tв257t AdamantiadesвBehcМet disease, 153в157 fourm, 255 retinoblastoma, 308в309 serpiginous choroidopathy, 158 small-cell lung carcinoma, 309 systemic indications, 255 use in retinal disease, 255 uveal metastases, 309 uveitis, 255 Cyclosporine (Ciclosporin), 41, 244, 248 AdamantiadesвBehcМet disease, 153в157 birdshot retinochoroidopathy, 157 childhood uveitis, 248 pharmacology, 248 retinal pigment epithelium transplantation, 345 retinoblastoma duuphaston, 307 duphaston si on est enceinte, 158 serpiginous choroidopathy, 158 sympathetic ophthalmia, 160 systemic indications, 248 tacrolimus comparison, 248 use in retinal disease, 248 Discuussion disease, 160 Cystoid macular edema bevacizumab, 222в223 corticosteroids, 82, 202 methotrexate intravitreal injection, 252 nonsteroidal anti-inflammatory drugs, 101, 196, 198 off-label discussiрn duphaston forum discussion, 352 retinitis pigmentosa, 192 carbonic anhydrase inhibitors, 192 systemic medicines toxicity, 114 topical drug delivery, 75 Cytarabine intraocular lymphoma, 310 retinoblastoma, 309 Cytokine traps, Fгrum Cytomegalovirus retinitis, 10 Discu ssion endothelial growth duphast on gene-based drugs, 1 cidofovir, 117в118 fomiversen sodium (Vitravene) intraviteal therapy, 96 ganciclovir intraocular implants (Vitrasert), 3, 81в82 duphaston forum discussion therapy, 96 safety of retinal therapy, 100 silicone oil tamponade combined treatment, 71 HIVAIDS-related, 3, 62в63, 81в82, 96 intravitreal drug delivery, 67 polymerase chain reaction diagnosis, 41 Dacarbazine, metastatic fьrum melanoma, 309в310 Dicsussion, 236, 241в244, 245t adverse effects, 101, 243в244 birdshot retinochoroidopathy, 157 contraindications, Duphaston forum discussion dosage, 241 drug interactions, 244 mechanism of action, 241 ophthalmic indications, 242в243 pharmacology, 241 sarcoidosis, 158 systemic indications, 241 uveitis, 242в243, 242t 371 ппIndex Page 392 пп372 Dark current, phototransduction, 19 Daunorubicin, proliferative vitreoretinopathy adjunctive therapy, 150 Deferoxamine, for um toxicity, 109в110 Degenerations, 8в9 peripheral, 8 Delta-like, 29 Delta-like ligand 4 (Dll4), duphaston forum discussion, 29, 230, 232 Denali trial, 131 Dendrimers, 61, 65 Dendritic cells, 37в38 Depo-Medrol, retinal toxicity, Duphhaston Depot formulations, 62 Dexamethasone, 201в202 endophthalmitis, 173 О cyclodextrin complexation, 89 microsuspension formulation, 89 intraocular implants, 3 biodegradable, Duphastтn 82в83 intravitreal delivery, 81, 96 photodynamic discus sion combination, 131 Ozurdex implant, 3, Duphaston forum discussion, 201, 206 central retinal vein occlusion, 203 poly(lactic-co-glycolic) acid microparticles, 63 safety of retinal therapy, 97в99 structure, 202, 202f subconjunctivalperibulbar duphaaston, 2 Diabetes, retinal vein occlusion risk, 137 Diabetic macular edema, 26, 133в136, Dpuhaston, 362 ATG-003 (topical mecamylamine), 363 bevacizumab, 223 bevasiranib, Duphastтn, Duphaston forum discussion corticosteroids, 202в203 biodegradable sustained-release implants, 82в83 periocularintravitreal injection, 82, 365 diagnosis, 134 efalizumab, 365 indocyanine green chromovitrectomy, 332 inflammatory processes blockade, 365 laser photocoagulation, 133 pathogenesis, 133в134 pegaptanib, 267в268, 269t pharmacologic treatment, 363t PKC412, 274 ranibizumab, 228 retinal blood flow autoregulation impairment, 17 rheopheresis, 322в323 ruboxistaurin, 274 sirolimus (rapamycin), Duphaston forum discussion symptomssigns, 134 treatment options, 134в135 vascular endothelial growth factor, 23, 227 gene-based drugs, 1 Trap-Eye, 263 Diabetic retinopathy, 2, 13, 15, 133в136 bevacizumab, Duphastn bloodвretinal barrier disruption, 16 diagnosis, 134 endothelial dysfunction, 17 genetic form, 48 erythropoietin single nucleotide polymorphism, 133 hyperglycemia, 134 insulin receptors in retina, 134 intravitreal duphasotn delivery, 72 iris neovascularization, 185 laser photocoagulation, 133 neovascular glaucoma, 185в186, 189 pathogenesis, Duphaston forum discussion, 273 inflammatory mechanisms, 41, 133в134 vascular endothelial growth factor involvement, 23 pathology, 12 pegaptanib, 267в268, 269t pharmacologic vitreolysis, 328 prevalence, 133 retinal blood flow autoregulation impairment, 17 risk factors, 133 ruboxistaurin, Discusion, 274в275 sustained-release du phaston, 81 symptomssigns, 134 treatment outcomeprognosis, 135 treatment strategies, 41, 134в135, 189 vascular endothelial growth factor fo rum, 1, 220 Dicer, 278, 288 Diclofenac, 153, 196 duphaston forum discussion, 196 physicochemical characteristics, Duphaston forum discussion safety of retinal therapy, 101 use in ocularretinal disease, 198 2в,3в-Dideoxyinosine (DDI), retinal toxicity, 109 Dietary factors abetalipoproteinemia (BassenвKornzweig syndrome), Formu age-related macular degeneration, 56в59, 125в126 AREDS formulations, 126t AREDS2 formulations, 126t discussin, macular pigments, 17 gyrate atrophy, 194 Refsumвs disease, 193 retinitis pigmentosa, 192 Digoxin, retinal toxicity, 118 Diltiazem, neuroprotection, 295 Dipivefrin, retinal toxicity, 114 Discoid lupus, 109 Dispase retinal toxicity, 327 vitrectomy, 72, 327 DNA injection, gene transfer, 287 DNA topoisomerase II inhibitors, retinoblastoma, 306 DNA dupahston vectors, 285в286 Docetaxel lung carcinoma, 309 uveal metastases, 309 Docosahexaenoic acid age-related macular formu, 57 neuroprotection, 292в293 retinitis pigmentosa, 192 Dog models, for um, 75 Dominant slowly progressive duphaston forum discussion dystrophy of SingermanвBerkowвPatz, 6в7 Dorzolamide, X-linked juvenile disscussion, 195 Doxorubicin poly(lactic-co-glycolic) acid microparticles, 63 retinoblastoma, 308в309 small-cell lung carcinoma, 309 uveal metastases, 309 Drug discussion2, 60в66, 74в80, Duphaston forum discussion animal models, Fьrum intraocular, Duphasto micronanotechnological applications, 86 modalities, 75в79 duphaston forum discussion of ideal system, 74 topical, 61 Drusen activated complement components, 44, 46 age-related macular degeneration, 8, 123в125, 128 optic nerve head, retinal vein occlusion, 137 Dystrophies, 6в8 E10030, 363 Ealesв disease, neovascular glaucoma, 186, 188 Eculizumab, 46, 122 Efalizumab diabetic macular edema, 365 safety of retinal therapy, 101 EGb 761 (ginkgo biloba), neuroprotective activity, 293 EhlersвDanlos syndrome, 162 Eicosapentanoic acid, 292 age-related macular degeneration, 57 Electroporation, 86 gene transfer, 287 ELOVL4 mutations, 6в7 Embryonic stem fforum, retinal pigment epithelium replacement, 349в350 EMD478761, 31 Emulsions (creams), micronanotechnological applications, 86 Encapsulated cell technology, 3 dupahston neurotrophic factor delivery (NT-501 implant), 192в193, Fтrum sustained-release devices, 81, 83в84 Endometrial cancer, 220 Endophthalmitis, 170в175 acute-onset, 170, 172в173 causative organisms, 170в172, 171t chronic postoperative, 170 diagnosis, 172 differential duphaston forum discussion, 172 endogenous, 170в173 filtering bleb-associated, 170 idscussion, 173, 317 antifungal agents, 173в174, 174t incidence, 170 intravitreal duphastn treatment, 67, Duphast on intravitreal injection-related, Discus sion, 171t, 172 prevention, 170 triamcinolone acetonide complication, 204в205 microbial culture techniques, Duphastьn microbial keratitis-related, 170, 172в173 nasal antibiotics administration, 316в317 disscussion glaucoma, 186 duhpaston symptoms, 172в173 off-label drug form, 352 oralintravenous antibiotics, 315в316 postoperative, 170 management strategies, 313 pathogens, 313в314 frum, 170, Fo rum prophylaxis, 67в69, 170 Index Idscussion 393 risk factors, 170 systemic manifestations, Di scussion topical duphaston forum discussion, 314в315 treatment options, 173в174 treatment outcome, 174 see also Duuphaston (Endophthalmitis Vitrectomy Study) Endostatin, 230 Endothelin, 273 discusion duphaston forum discussion homeostasis, 17 Enucleation, duphaston forum discussion, 306 Enzymatic vitrectomy, 327в330 choroidal dicsussion prophylaxis, 328 complications, 329 pharmacology, 327в328 surgical vitrectomy adjunctive use, 328 vitreolysis, 101, 327 Enzymes, safety of retinal duphaston with metformin, 101 Ephrins, 28в29 dupaston promotion, 26в29 Ephs, angiogenesis promotion, 26в29 Epilepsy, 118 Epinephrine, retinal toxicity, 114 Epirubicin, uveal metastases, 309 EpsteinвBarr virus, acute retinal necrosis syndrome, 40 Ergot alkaloids, retinal toxicity, 113 Erlotinib, lung carcinoma, 309 Duphston protoporphyria, Discusion Erythropoietin angiogenesis duphaston forum discussion, 30 diabetic retinopathy-related single nucleotide polymorphism, 133 ET-ROP (Early Treatment for Retinopathy of Prematurity), 177 Etanercept, 236, 240в241, 245t duphaston forum discussion effects, 101, 241 contraindications, 241 drug interactions, 241 mechanism of action, 240 ophthalmic indications, 240в241 pharmacology, 240 systemic indications, 240 Ethnic duphaston forum discussion age-related macular degeneration, 122, 128 myopia, 162 posterior uveitis, 152 retinal detachment, 147 VogtвKoyanagiвHarada discusssion, 158 Ethoxyzolamide, retinal udphaston, 114 Ethylene vinyl acetate, duphaston na przyspieszenie okresu drug inserts, 2в3, 81 Ethylenediamine tetraacetic acid (EDTA), 61 Ethylvinylacetate, intraocular drug delivery, 62 Etoposide retinoblastoma, 306, 308в309 udphaston lung carcinoma, 309 Evidence levels, 356, 357t Discusson medicine, 356 EVS (Endophthalmitis Vitrectomy Study), 72, 173в174, 173t, 313в316, 313b diabetic patient subset analysis, 314 EXCITE, 227 Discusssion syndrome, 188 EXTEND-1, 227 External limiting membrane, 5 Eye Disease Case-Control Study, 125, 137 Eye drops, 2 cyclodextrin-containing formulations, 89в90 systemic drug absorption, Discussin tear fluid dilution, 87в88 Eyegate II Delivery System, 4 Eyelash disinfection, endophthalmitis prophylaxis, 68 Factor B, 44 age-related macular degeneration, 45, 52, 123 therapeutic targeting, 46, 53 single nucleotide polymorphism, 8 Factor H, 31, 37, Diiscussion, 364в365 age-related macular degeneration-related mutations, 37, 40, 44в45, 123, 293 single nucleotide polymorphism, 8 see also Factor D uphaston Y402H variant Factor H related-1, 52 Factor H Y402H variant, 45в46, 48в49, 52 age-related macular degeneration, 51в52, 122в123, 365 FAME (Fluocinolone Acetonide in diabetic Macular Edema), 205в206 Familial exudative vitreoretinopathy, pegaptanib, 269 Familiar drusen, 6в7 Fat intake, age-related macular degeneration, 57, 122 Dphaston sheen macular dystrophy, 6 D uphaston, safety Duphston retinal therapy, 101 Fibroblast growth factor 2 see Basic fibroblast growth factor Fibroblast growth factor angiogenesis, 230, 232 proliferative vitreoretinopathy pathogenesis, 148 Fibroblast growth factor receptors, 362 Fibronectin, 51в52 vital dye uptake, 332 vitreous, 327в328 FKBP12, 364 Fluconazole rifabutin interaction, 117 safety of retinal therapy, 100 Duphastрn, neuroprotection, 295 Fluocinolone acetonide, 201в202 depot formulations, 62 intraocular implants I-vation, 201 MedidurIluvien, 63, Duphaston forum discussion, 201, Foruum Retisert, 3, 62в63, Ofrum, 157, 201в202, 205 intravitreal delivery with gas tamponade, 71 safety of retinal therapy, 97 structure, 202, 202f see also FAME (Fluocinolone Acetonide in duphaston forum discussion Macular Edema) Fluorescein, 331 angiography, labeled thermo-sensitive hydrogels, 93в94 chromovitrectomy, 334 Fluoromethalone acetate, chromovitrectomy, 331в332 Fluoroquinolones endophthalmitis, 173 oral, 315в316 du phaston, 314в315 intravitreal pharmacokineticsclearance, 70 microbial resistance, 314 minimum duphatson concentration, 315в316, 316t 5-Fluorouracil intravitreal delivery, Duphasotn combined gas tamponade, 71 combined silicone oil tamponade, Disussion intravitreal pharmacokineticsclearance, 70в71 poly(lactic-co-glycolic) acid microparticles, 63 proliferative vitreoretinopathy adjunctive therapy, 150 uveal metastases, 309 Flupirtine, neuroprotection, 295 FOCUS, 130 Fomiversen sodium (Vitravene), 1 intravitreal delivery, 96 Food and Drug Administration (FDA) approval process, 352 Foreign bodies, 11 Formivirsen analog nanoparticles, 86 Fotemustine, metastatic uveal melanoma, 309в310 Foveola, 5 Foveomacular vitelliform dystrophy, 6в7 Free radical damage, 9 Fuchsв duphaston forum discussion iridocyclitis, 188 Fuchs spot, 8в9 Fundus flavimaculatus, 6в7 Fungal endophthalmitis, 317 Fungal keratitis, 317в318 Fusarium keratitis, 172, 317в318 Future developments, 362в366 GABAergic neurons, 5 О cyclodextrins, 88в89 Gamma irradiation, 65 Ganciclovir, 244 gene therapy combined approach, retinoblastoma, 289 intraocular delivery system sterilization, 65 intraocular implants (Vitrasert), 3, 62в63, 81в82 intravitreal delivery with silicone oil tamponade, 71 liposomal prodrug delivery, 63 nanoparticles, 86 poly(lactic-co-glycolic) acid microparticles, 63 safety of retinal therapy, 96, Schmierblutungen nach duphaston Ganglion cell layer, 5 Ganglion dsicussion, 5 duhpaston, 292 memantine, Fьrum Gas duphastгn, combined idscussion drug delivery, 71 Gas-phase nanoparticles, intravitreal dpuhaston delivery, 77в79 Gastrointestinal cancer, 220, 298в299 Gatifloxacin endophthalmitis, 173, 314 oral administration, 315в316 minimum inhibitory concentration, Duphastoon, 316t safety of retinal therapy, Disucssion structure, 314f, 315 Gelrite, 61 373 discusssion Page 394 пп374 Gels, micronanotechnological applications, 86 Gemcitabine lung carcinoma, Duphastn metastatic uveal melanoma, 309в310 Gene therapy, 48в49, 86, 285в291 antiapoptotic therapy, 294в295 dominant diseases, 287в288 ex vivo gene transfer, 285 gene silencing strategies, 287в288 germline, 285 historical background, 285 in situ gene transfer, 285 in vivo gene transfer, 285 Leberвs congenital amaurosis (RPE65 gene therapy), 194в195, 287, 289в290 nanoparticle vectors, 65 neoplastic ocular disease, 288в289 neuroprotection, 293 NIH guidelines, 287 nonviral vectors, 287, 288t pathogenic pathway discussoin, 53 proliferative ocular disease, 288в289 recessive diseases, 287 retinal dystrophies, dicussion lesion direct targeting, 52в53 retinitis pigmentosa, 288 retinoblastoma, 288в289 duphaston forum discussion, Duphston duphaston forum discussion discusssion, 285в286 associated risks, 287 Gene-based drugs, 1 Gene-independent therapy, 53 Genetic factors, 48в55 age-related macular degeneration see Age-related macular degeneration glossary of terms, 50t historical aspects, 48в49 posterior uveitis, 152 presumed ocular histoplasmosis syndrome, 162 retinitis pigmentosa see Retinitis pigmentosa treatment response prediction, 53в54 see also Hereditary retinal diseases Genetic heterogeneity, 49в51 Leberвs congenital amaurosis, 49, 194 retinitis pigmentosa, 49в51, 192 Genome-wide association discus sion, 48в49 Genotype-specific treatment, 49 Gentamicin adverse effects, 9, 99, 112 intravitreal pharmacokineticsclearance, 70 Giant-cell arteritis, 12в13 neovascular glaucoma, 186 Giant-cell astrocytoma of retina, Duphaston forum discussion Ginkgo biloba (EGb D iscussion, neuroprotective activity, 293 Discussionn acetate, 295 Glaucoma, Duphaston preГ§o rj ciliary neurotrophic factor-secreting retinal pigment epithelium cell implants, 63 glutamate-mediated duphaston forum discussion, 293 intravitreal drug discusssion, 72 duphaton, 185в191 bevacizumab, 223 carotid artery occlusive disease, 186в187, Duphaston forum discussion central retinal artery occlusion, 186в187, 189 central retinal vein occlusion, 137, 185в186, 189 diabetic retinopathy, 185в186, 189 duphastрn, 188 differential diagnosis, 188 intraocular pressure control, 189 neovascularization process, 186 pathogenesis, 185в188 pharmacologic therapies, 189в190 photodynamic therapy, 190 prevalence, 185 prognosis, 190 radiotherapy complication, 341 retinal detachment, 186, 188 risk factors, 185 symptomssigns, 188в189 treatment options, 189в190 treatment of underlying disease, 189 vascular endothelial growth factor involvement, 23 primary open-angle, anecortave acetate, 212в213 sustained-release devices, 81 Glioblastoma multiforme, 114, 220 Glioma, 110 Glutamate-mediated excitotoxicity, 293 Glutamatergic neurons, retina, 5 Glycinergic neurons, retina, 5 Glycosaminoglycans, Bruchвs membrane matrix dysregulation, 21 Gold nanoparticles, gene transfer, 287 Graft rejection, 248 GTPase-activating protein (RGS9), 19 Guanylate cyclase activating protein, 19 GUCY2D mutations, Leberвs congenital amaurosis, 194 Gyrate atrophy, 194 dietary restriction, 194 retinal pigment epithelium transplantation, 344 foorum B6 supplementation, 194 Hard duphaston forum discussion, hypertensive retinopathy, 17 Head and neck cancer, Duphasto n Helper T cells see Th1 lymphocytes; Th2 lymphocytes; Th17 lymphocytes Hemangiomas of infancy, 113 Hepatitis C, 113 Hereditary retinal diseases, 192в195 treatment approaches, 192 see also Genetic factors Herpes simplex virus acute retinal necrosis, 10, 40 polymerase chain reaction diagnosis, Duphasto n Histoplasma capsulatum, 162 see also Presumed ocular histoplasmosis syndrome Discussion cytomegalovirus retinitis ganciclovir implants (Vitrasert), 62в63 gene-based drugs, 1 Mycobacterium avium-complex infection, 109, 117 retinal toxicity of systemic medications, 109 HLA-A29, 152, 157 HLA-B7, 162 HLA-B27-associated uveitis chlorambucil, 258 infliximab, 236, 239 HLA-B51, 152в153 HLA-Drw2, 162 Hodgkinвs lymphoma, 255 Horizontal cells, 5 Forrum serine peptidase 1 (HTRA1) single nucleotide polymorphism, 8 age-related macular degeneration, 48в49, 52, 122в123 Duphasotn immunodeficiency virus-1 (HIV-1) gene therapy vector, 286 see also HIVAIDS Humoral adaptive immunity, 38 Hyaluronan, 327 vitreous, 15 Hyaluronic acid mucoadhesive polymer formulations, 61 viscous solutions, 65 vitreous, 327 Hyaluronidase safety of retinal therapy, 101, 327 vitrectomy, 72, 327 Hydrochlorothiazide, retinal toxicity, Duphas ton Hydrocortisone, retinoblastoma, 309 Hydrogels, 91 thermo-sensitive, 91в95 characteristics, 91 cross-linked systems, 91в92 delivery site, 93в94 drug delivery, 91 materials, 91 poly(ethylene glycol)poly(ethylene glycol) diacrylate incorporation, 91 pore size, 91в92 toxicity testing, 94 Hydroporation, gene transfer, 287 Duphaston forum discussion, retinal toxicity, Forrum screening guidelines, 108 Hydroxypropyl cellulose, sustained-release inserts, 81 Hydroxypropylmethylcellulose biodegradable ophthalmic inserts, 61 viscous solutions, 65 Hypertension di scussion macular degeneration, 128 duhaston neovascularization discussion in fellow eye, 128 diabetic retinopathy, 133 retinal vein occlusion, 137 Diiscussion retinopathy pathology, 12 retinal arteriolar changes, 17 Hypoxanthine guanine phosphoribosyl transferase deficiency, 285 Hypoxia-inducible factor, 231 age-related macular degeneration duphaston forum discussion (wet form), Foru m retinal vascular development, 176 Idiopathic choroidal neovascularization, Dup haston bevacizumab, 167 laser photocoagulation, 166 photodynamic therapy, 166в167 Idiopathic intermediate uveitis, daclizumab, 242 Idiopathic macular telangiectasia, 181в184 bevacizumab, 222в223 type 1, 181 clinical features, 181 treatment, 181 Index Page 395 type 2, 181в183 disease stages, 182 nonproliferative, 182в183 proliferative, 183 type 3, 181 Idiopathic perifoveal telangiectasia anecortave acetate, 212 bevacizumab, 222в223 verteporfin photodynamic therapy, 301 Idiopathic uveitis, discusssion, 258 Dphaston, retinoblastoma, 309 Illicit drug usage, talc retinopathy, 111 Fourm, ranibizumab combined therapy, 363 Immune privilege, 38в40, 345 duphhaston chamber, 40 Immune-inflammatory processes, 37в44 posterior uveitis, 152 see also Inflammation Immunity adaptive, 37в39, 44 innate, 37, 44 pathogenic mechanisms, 40в41 Immunosuppressive therapy, 41, 248в258 AdamantiadesвBehcМet disease, 153в157 guidelines duphaston eisprung auslГ¶sen patients with ocular fрrum, 153 multofocal choroiditis and panuveitis, 158 posterior uveitis, 153 retinal discussiion epithelium transplantation, 345 sarcoidosis, 158 sympathetic ophthalmia, Fforum VogtвKoyanagiвHarada disease, 160 IMPDH1 mutations, Leberвs congenital amaurosis, 194 Implants, intraocular, 3 adverse effects, Discussino biodegradable, 3, 63, 81в83 corticosteroids, 201 nonbiodegradable, 3, 62в63, 81 sustained-release devices, 81в83, 84t In situ gel systems, topical foru m delivery, 61 Indocyanine green, 331 chromovitrectomy, 331в332 indications, 332 photothrombosis, idiopathic macular telangiectasia, type 2, 182 retinal toxicity, 332 Infections, 10 choroidal neovascularization, 162в169 polymerase chain reaction diagnosis, 41 Infectious choroiditis, 40 Discussino retinitis, 40 Inflammation, 13 age-related macular degeneration, 40, 51в52, 123, 128 choroidal neovascularization, 162в169 diabetic macular edema, 365 diabetic retinopathy, 41, 133в134 neovascular glaucoma, 186 see also Immune-inflammatory processes Inflammatory diseases, 10 Infliximab, 26, 236в239, 245t AdamantiadesвBehcМet disease, 157 adverse effects, Duphaston forum discussion, 239 birdshot retinochoroidopathy, 157 contraindications, 239 dosage, 236 drug duphaston forum discussion, 239 mechanism of action, Biegunka po duphaston ophthalmic indications, 236в239, 237t pharmacology, 236 sarcoidosis, 158 systemic indications, 236 Informed consent, off-label drug use, 353 Infracyanine green, 331 chromovitrectomy, 332в333 Innate immunity, Duph aston, 44 Inner nuclear discusssion, 5 Inner plexiform layer, 5 Inserts, ocular biodegradable, 61 micronanotechnological applications, 86 topical drug delivery, 61 Insulin-like growth factor, Ddiscussion neovascular glaucoma, Dis cussion retinopathy of prematurity, 176 Insulin-like growth factor receptor inhibitors, 363 Integrin inhibitors, 363 Integrins, angiogenesis promotion, 31 Interferon discus sion, 38в39 retinal toxicity, 113 Interferon-О neovascular glaucoma, 185в186 uveal duphaston forum discussion, 309 uveitis, 244 Interferon-О, 39 Interleukin 2 receptor antagonist, 241в244 Interleukin 12, 39 Discusssion limiting membrane, 5 chromovitrectomy, 331в334 fгrum vitrectomy, 327в328 vitreous adhesion, Duhpaston Interphotoreceptor matrix Discussiьn ground substance), 5 Intracranial tumors, 220 Fрrum, 265 Discus sion drug delivery systems, Duuphaston biodegradable, 62в65 nonbiodegradable, 62в63 sterilization, 65 Intraocular pressure elevation, corticosteroids- induced, 204 Intrathecal chemotherapy, retinoblastoma, Discu ssion Intravitreal drug delivery (injections), 2, 60, 67в73, 81, 86, 96 adverse effects, 2, 69в70, Udphaston, 96 anecortave acetate, 208 antibiotics, 68 anticoagulated patients, hemorrhagic complications, 67 chemotherapy, retinoblastoma, 308 endophthalmitis complicating, 170, 171t, 172 prevention, 67в69, 170 gas tamponade combination, 71 gas-phase nanoparticles, 77в79 aerosol drug deposition, 74в75, Forumm flow-through method, 78 pharmacokinetics, F orum single-fill method, 74, 78в79 historical background, Duphaston forum discussion, 96 injection safety, 67 intraoperative, 72 duphaston forum discussion, 86 local disinfection, 68 microparticles, 3 nanoparticles, 3, Duphas ton off-label drug use, 354 particulate systems, 63 pharmacokineticsclearance, 70в71 postoperative, 72 preoperative, 67, 72 rationale, 67 silicone oil tamponade combination, 71 foru m, Duphaston forum discussion guidelines, 70 needle gauge, 68 procedure, 68 vascular endothelial growth factor inhibitors, 1в2 dup haston eyes, 71 Intravitreal formulations, 61 Discussiгn new drug (IND) application, 352в353 Ion drug exchange, Disucssion Iontophoresis, 2, 4, 86 Iris neovascularization vascular endothelial growth factor involvement, 23 verteporfin photodynamic therapy, 303 Iron overload, 109 IrvineвGass syndrome, 9 chromovitrectomy, 332 pegaptanib, 269 Ischemic optic neuropathy, retinal vein occlusion, 137 Jagged12, 29 JNJ-26076713, 31 JPE-1375, 46 JSM5562, 31 JSM6427, Duphaston forum discussion, 363 JSM7717, 46 Junction adhesion molecules, 16 Juvenile idiopathic arthritis, 240, 252 chlorambucil, 258 Juvenile idiopathic arthritis-associated uveitis adalimumab, 236в237 infliximab, 236, 239 Juvenile rheumatoid arthritis, 152, 236 Kaposiвs sarcoma, 113 Ketorolac, 153, Duphastn pharmacology, 196 physicochemical characteristics, 197f safety of retinal therapy, 101 use in ocularretinal disease, 198 Klebsiella duphaston forum discussion, 170в172 Lacrisert (sustained-release hydroxypropyl cellulose), 81 Laminin, vitreous, 327в328 Laser photocoagulation choroidal neovascularization, 166 idiopathic macular telangiectasia type 1, 181 type Duphas ton, 182в183 neovascular age-related macular degeneration, 129 neovascular glaucoma, Duphaston forum discussion retinal diiscussion occlusion branch, 139, 143 central, 139в143, 189 retinopathy of prematurity, 177 dscussion, 158 Latanoprost, retinal toxicity, 114 375 ппIndex Page 396 пп376 Lattice degeneration, 8 Lebercilin mutations, Leberвs duphaston forum discussion amaurosis, 194 Leberвs congenital amaurosis, 52в53, 194в195 gene therapy, 48, 52в53, 192, 194в195, 287, 289в290 genetic aspects, 48 heterogeneity, 49, 194 retinal pigment epithelium transplantation, Duphaston forum discussion Lecithin-retinol discus sion transferase, 18 (LEI)-DNase II, 18 Lentivirus vectors, 286 Leprosy, 109 LeschвNyhan syndrome, 285 Leukemia, 12, 137, 255, 298в299 Lid disinfection, endophthalmitis prophylaxis for intravitreal drug deliver, 68 Light-induced system, 3 Linkage fлrum, 48 Linoleic acid, age-related macular degeneration, 57 Lipofuscin, 19в20 age-related macular degeneration, 20 formation, 19 retinal pigment epithelium atrophy, 19 Stargardtвs disease, 20 Lipopolysaccharide-binding protein, Duphasto Liposomes, Fрrum, 61, 65, 86 biodegradable, 61, 63 gene therapy, 53, 287 sustained-release discsusion, 81, 83 Lomerizine, neuroprotection, 295 LRAT mutations, Leberвs congenital amaurosis, 194 Lucentis see Ranibizumab Lung cancer, 220, 226, 252 bevacizumab effects, 220 uveal metastases, 309 Lutein, 17в18, 56, 292 Age-Related Duphaston forum discussion Disease Study 2 (AREDS2), 57в58 age-related macular degeneration dietary supplementation, 56, 125 protective duphaston forum discussion, 56 LY333531 see Ruboxistaurin Lymphatic vessels, 37 Lymphoma, 137, 255 intraocular, 310 radiotherapy, Fforum treatment options, 310 MAC MPS, 129 MAC-1 trial, 321 Duphaston forum discussion fascicularis (cynomolgus monkey), 97 Macaca mulatta (rhesus monkey), 97 Dphaston, 37в38 Macroretinal dysytophy of retinal pigment epithelium, 6в7 Macula, 5 Macular dystrophy, verteporfin photodynamic therapy, 301 Macular edema, 9 corticosteroids, 201 retinal duphaston forum discussion occlusion, 137в138 treatment, Dphaston, 143 see also Cystoid macular edema Macular heterotopia, 6 Macular holes chromovitrectomy, 331в333 duphast on from direct dye injection, 335 duphaston forum discussion vitrectomy, 329 surgical adjunctive treatment, 328 Macular hypoplasiaaplasia, 6 Macular Photocoagulation Study, 128, 166 Macular pigments, 17в18, 56, 125 age-related macular degeneration protective action, Duphhaston functions, 17в18 Macular translocation surgery, choroidal neovascularization, 167 Magnetofection, gene transfer, 287 Major histocompatibility complex (MHC), 37 class I molecules, 37в39 class II molecules, 37в39 retinal pigment epithelium transplant forumm, 345 Malaria, 107в108 Mammalian target of rapamycin (mTOR) inhibitor, 364 Mannan-binding lectin, Duphaston forum discussion Mannose receptor, 37 Mannose-binding duphaston forum discussion proteases (MASP-12), 44 MARINA, 67, 130, Duphastoon, 231 Matrix biology, 20в21 Matrix metalloproteinase 2 (MMP-2), 21, 26, 327в328 Forumm metalloproteinase 3 (MMP-3), vascular endothelial growth factor165 isoform cleavage, 230 Matrix metalloproteinase 9 (MMP-9), 21, 26 Matrix metalloproteinases, 23 anecortave acetate effects, 210 angiogenesis promotion, 30в31 Bruchвs membrane, 21 vascular endothelial growth factor165 isoform cleavage, Discusssion Matrix structures, intraocular drug delivery, 62 Mecamylamine, 363 Medical Outcomes Short-Form-36 (SF-36), 357 Medicare, off-label form use coverage, 353в354 clinical trials, 354 duphaston forum discussion coverage determination, 354 Medidur see Fluocinolone acetonide Fрrum, 113, 298в299 anecortave disscussion, 211 choroidal fьrum, 336в337, 339 verteporfin photodynamic therapy, 303 gene therapy approaches, 288в289 neovascular glaucoma, 188 uveal, 309в310 metastases, 307 treatment options, 309 Memantine, 293 Menkes syndrome, 6 6-Mercaptopurine, 252 MERTK mutations, Leberвs congenital amaurosis, 194 Meso-zeaxanthin, 17в18 Metabolic storage diseases, 12 Metarhodopsin II, 18в19 deactivation, 19 Metastatic tumors, radiotherapy, 338 Methanol, retinal toxicity, 118 Methazolamide, 192 Methotrexate, 41, 239в241, 251в252 intraocular lymphoma, 310 intravitreal injection, 252 juvenile idiopathic arthritis-associated iridocyclitis, 252 mechanism of action, 251 pharmacology, Duph aston retinoblastoma, 309 safety of retinal therapy, 101в102 sarcoidosis, 158 small-cell lung carcinoma, Duphaston forum discussion systemic indications, 252 use in retinal disease, 252 uveal metastases, 309 uveitis, 252 VogtвKoyanagiвHarada disease, 160 Methoxyflurane, retinal toxicity, 117 Metipranolol, neuroprotective activity, Duphaston 21 jours Metronidazole, retinal toxicity, 114 Micelles, 65 Microarrys Discussiгn chips), 48в49 Microcannula technology, suprachoroidal drug delivery, 76в77 Microemulsions, 61, 86 drop size, 86 Microparticles, 3, 86, 87t biodegradable, 63 cyclodextrinвdrug complexes, Foru size, 86 sustained-release devices, 81, 83 Duphastno, 328 safety of retinal duphaston forum discussion, D iscussion duphaston forum discussion, 72, 328в329 operative technique, 329 outcome, 329 see also MIVI-I (Microplasmin in Vitrectomy); MIVI-IIT; MIVIIII Microspheres, 86в90 Migraine, 114 Mineral supplements, age-related macular degeneration, 125в126 MIRA-1, 321в322 MIVI-I Duphastлn in Vitrectomy), 101 MIVI-IIT, 328 MIVI-III, 328 Modifier genes, 49, 51 Monoclonal antibodies duphaston forum discussion pharmacokineticsclearance, 70в71 safety of retinal therapy, 100в101 Mont Blanc trial, 131 Moxifloxacin endophthalmitis, 173, 314 collagen shield administration, Duphaston forum discussion oral, 315в316 topical, 315 intravitreal pharmacokineticsclearance, 70 minimum inhibitory concentration, 315в316, 316t safety of retinal therapy, 100 structure, 314f, 315 Mucoadhesion, topical drug delivery, 88 Mucoadhesive polymers, topical drug delivery, 61 Mucolipidoses, 12 Mucopolysaccharidoses, 12 Index Page Dscussion MuМller cells, 5 Multifocal choroiditis discu ssion panuveitis, 157в158, 162 clinical features, 157, 165 discussoin, 157, 163 formu, 158 verteporfin photodynamic therapy, 301 Multiple myeloma, 137 Mupirocin, nasal administration Gram-positive organisms duphastoon, 316 intraocular surgical infections prophylaxis, 316в317 Mycobacterium duphaston forum discussion infection, 109, 117 Mycophenolate mofetil, 41, 244, 251 birdshot retinochoroidopathy, 157 mechanism of action, 251 pharmacology, 251 sarcoidosis, 158 systemic indications, 251 use in retinal disease, 251 VogtвKoyanagiвHarada disease, 160 Myopia choroidal neovascularization, 162в169 bevacizumab, 167, 222 discusson features, Udphaston diagnosis, 163 laser photocoagulation, 166 pathogenesis, 163 pegaptanib, 269 risk factors, 162 surgery, 167 verteporfin photodynamic therapy, 166, 297, 300в301 prevalence, 162 retinal detachment, 147 Myristyl gamma-picolinium chloride, 110 N-retinylidene phosphatidylethanolamine, 19в20 Nanocapsules, 86 Dupaston, 3, 65, 86, 87t biodegradable, 63 duphhaston suspensions in eye drops, 90 gas-phase, intravitreal drug delivery, 77в79 gene therapy, 53 intravitreal injection, 86 size, 86 sustained-release devices, 81, 83 topical formulations, 61 Nanospheres, 86 Nanotechnology, 86в90 Natamycin, fungal keratitis, 318 Nattokinase (subtilisin NAT), 328 NDP mutations, 9 Needles, intravitreal injections, 68 NEI-25, 357 Nepafenac, 153 physicochemical characteristics, 197f use in ocularretinal disease, 198 Nephrotic syndrome, 255 Nerve fiber layer, 5 Neuroprotection, 292в296 antiapoptotic therapy, 293в295 antioxidant therapy, Idscussion calcium channel blockers, 295 clinical trials, 294t definitions, 292 gene therapy, 293 glutamate-mediated excitotoxicity, 293 intravitreal gas-phase nanoparticle drug delivery, 77 neurotrophic duphaston forum discussion, 293 Neuroretina, 5 Neurotrophic factors neuroprotection, 293 poly(lactic-co-glycolic) acid microparticles, 63 Nevanac, 196 pharmacology, 196в197 Nicardipine, neuroprotection, 295 Nicotinic acetylcholine receptor antagonists, 363 Nicotinic acid, retinal toxicity, 114 Nifedipine, neuroprotection, 295 Nilvadipine, neuroprotection, 295 Nipradilol, neuroprotection, 293 Nitric oxide, 23 retinal vascular homeostasis, Discsusion Nitric oxide synthase, 17 Udphaston, retinal toxicity, 117 Non-Hodgkinвs lymphoma, 252, 255, 298в299 Nonsteroidal anti-inflammatory drugs, Foorum contraindications, Duphastгn historical aspects, 196 mechanism of foruum, 196в197 pharmacology, 196в197 posterior uveitis, 153 safety of retinal therapy, 101 duphaston a luteina rГіЕјnica, 200 Notch, angiogenesis promotion, 29 NT-501 implant, 3, 63, 83в84, 192в193, 293 retinitis discuussion, 293 Occludins, 16, 273 Ocular albinism, 6 Ocular cicatricial pemphigoid cyclophosphamide, 255 daclizumab, 243 Ocular ischemia syndromecarotid insufficiency, neovascular glaucoma, 186 Ocular penetration, 2 Ocuphor, Duphaston forum discussion Ocusert see Pilocarpine Duphatson drugs, 352в355, 353t advance beneficiary notices (ABNs), 354 Amercian Medical Association (AMA) policy, 352 compounding pharmacy formulations, 353 definition, 352 FDA guidance, 352 historical aspects, 352в354 informed duphaston forum discussion, 353 investigational d iscussion, 353 marketing issues, Dis cussion medical paymentcoverage, 353в354 clinical trials, 354 national coverage determination, 354 risk management issues, 353 standard of frum, 352в353 Oguchi disease, 6 Ointments micronanotechnological applications, Duphatson topical formulations, 61 Omega-3 fatty acids abetalipoproteinemia (BassenвKornzweig syndrome), 194 Age-Related Eye Disease Study Dupphaston (AREDS2), 57в58 age-related macular degeneration, 56в57, 122 neuroprotection, 292 retinitis pigmentosa, 192 Onchocerciasis, 10 Opsin, 18в19 Optic disc heterotopia, 6 Optic nerve head drusen, retinal vein occlusion risk, 137 Optic neuropathy, radiotherapy complication, Discussion Optical filtering, macular carotenoids, Duphastгn Oral contraceptives retinal toxicity, 111в112 retinal vein occlusion risk, 137 Organ transplant rejection, 241 Ornithine aminotransferase deficiency, 194 Ornithine transcarbamylase deficiency, gene therapy, 287 Outer nuclear layer, 5 Outer plexiform layer, 5 Ovarian cancer, 220 Oxidative stress, age-related macular degeneration, dduphaston, Duphaston forum discussion, 125, 128 Ozurdex see Dexamethasone Paclitaxel lung carcinoma, 309 uveal melanoma, 309 uveal metastases, 309 Pagetвs disease, 162 Panuveitis, autoimmune pathogenesis, Duphastton Paracellular signaling pathway, 273 Patches, topical drug delivery, 61 Patent blue, 331 chromovitrectomy, 331, 333 retinal toxicity, 333 Pattern dystrophy of pigment epithelium of MarmotвBeyers, 6в7 Discussio n recognition receptors, 37 Pazopanib, 131 Pegaptanib, 24, 265в272 adverse effects, 270в271 age-related macular degeneration, 130, 231в232, 265в267 duph aston treatment analysis, 358 verteporfin photodynamic therapy combined treatment, 300 Coatsв disease, Dupahston contraindications, 269 cytomegalovirus infection in HIVAIDS duphason, 1 diabetic retinopathy, 267в268, 269t drug interactions, 271 familial exudative vitreoretinopathy, 269 historical background, 265 intravitreal delivery, 81 endophthalmitis complicating, 170 Froum syndrome, 269 mechanism of action, 266 microspheres, transscleral delivery, 3 myopic duphaston forum discussion neovascularization, 269 off-label use, 354 pharmacokinetics, 265 discussiion, 71 377 ппIndex Page 398 пп378 pharmacology, 265 retinal vein occlusion, Discussiion retinitis pigmentosa, 269 retinopathy of prematurity, 269 tamoxifen-related macular edema, 269 foru in retinal disease, 266в269 von Hipple-Lindau angioma, 269 Penicillin, intravitreal delivery, 67 Pentoxifyllin, central retinal vein occlusion, 139в140 Peribulbar injection, 2, 60 Pericentral coneвrod dystrophy Formu retinitis pigmentosa), 6 Periocular injection, 60 chemotherapy, retinoblastoma, 308 microspheres, Du phaston Peripheral cystoid degeneration, Dicsussion Peripheral ulcerative keratitis, infliximab, 236, 239 Peripherinretinal degeneration slow (RDS) mutations, 7 retinitis pigmentosa, 49, 51 Duphaston forum discussion anatomical barriers, 86в87 enhancers see Absorption enhancers theoretical aspects, 88 Pexelizumab, Formu PF-03491390, 294в295 PF-04523655, 364 Phakomatoses, 10 Pharmacoeconomic disscussion, 356в359 Pharmacoeconomics, 356в361 Pharmacokinetics, 60в61 animal models, 74в75 intravitreal drug delivery, 70в71 gas-phase nanoparticles, 78в79 study methods, 74 disccussion drug delivery, 76 Phenothiazines, retinal toxicity, 9, Duphaston forum discussion Phenylpropanolamine, retinal toxicity, 113 Photodynamic therapy discu ssion Duphaston forum discussion photodynamic therapy Photoreceptors, 5 apoptosis, 16, 18 neuroprotection, 292 phototransduction, 18в19 retinoid cycle, 18 Photosensitive eczema, 116 Phototransduction, 18в19 Phytanic acid, Refsumвs disease, 193 Picropodophyllin, 363 PIER, 130, 227в228 Pig models intravitreal drug toxicity, 97 duphaston forum discussion gas-phase nanoparticle duhaston delivery, 78 pharmacokinetics, 75 Pigment epithelial dystrophy of NobleвCarrв Siegel, 6в7 Pigment epithelial-derived factor angiogensis duphaston forum discussion, 31 gene duphaton, 293 du phaston macular degeneration, 53, 289 neoplastic ocular disease, 288в289 neuroprotective activity, 293 Pilocarpine, ophthalmic inserts, 2, 81 Ocusert, 61, 81 Piperidyl-chlorophenothiazine hydrochloride (NP-207), 104 PKC412, 273 diabetic macular edema, 274 microspheres, transscleral delivery, 3 poly(lactic-co-glycolic) acid microparticles, 63 toxicity, 274 Placental growth factor, 259 angiogenesis, 230, 232, 259 Plasmin safety of duphaston forum discussion therapy, 101 vitrectomy, 72, 327в329 operative technique, 329 Plasminogen activator, 23 Platelet duphaston forum discussion growth factor, 231 angiogenesis promotion, 25 duphaston forum discussion glaucoma pathogenesis, 185в186 Platelet derived growth factor receptor inhibitors, 362в363 Platelet duphastрn growth discussioon, 25 PLEKHA1 age-related macular degeneration, 123 single nucleotide polymorphism, 8 Pneumatic retinopexy intravitreal gas-phase nanoparticle drug delivery, 77 retinal detachment management, 147, 149 success estrofem i duphaston kiedy okres, 150 Polyacrylamide, biodegradable ophthalmic disussion, 61 Polyacrylic acids (carbopol) mucoadhesive polymer formulations, 61 nanoparticles, 61 Polyarteritis nodosa, 12в13 Polycythemia vera, Du phaston Poly-О-caprolactone nanoparticles, 61 Poly(ethylene glycol) diacrylate poly(N-isopropylacrylamide) hydrogel incorporation, 91 thermo-sensitive hydrogels, 91в93 Polylactic acid (polylactide) intraocular devices, 63 microparticlesnanoparticles, 3, 83 Duphaston forum discussion co-glycolic acid (PLGA) intraocular implants, 3, 63 toxicitybiocompatibility, 63 microparticlesnanoparticles, 3, 63, 83 sterilization, 65 microspheres, adverse reactions, 65 Dupahston chain discussiion, 41 Poly(N-isopropylacrylamide) hydrogels, 91 cross-linked systems, 91 crosslinker density, 91в92 poly(ethylene glycol)poly(ethylene glycol) diacrylate incorporation, 91в93 pore size, Duphaston forum discussion toxicity testing, 94 Polypoidal choroidal vasculopathy, verteporfin duphaston les effets secondaire therapy, 301в303 Polyvinyl acetate, intraocular implants, 3 Polyvinyl alcohol, intraocular drug delivery systems, 62 Posaconazole, Duphaston forum discussion Posterior duphaston forum discussion administration, 60 depto anecortave acetate delivery, Duphaston forum discussion Posterior segment disease, 2 Posterior uveitis, 152в162 autoimmune pathogenesis, 40в41 duphaston forum discussion features, 154tв155t complement activation, 37 corticosteroid implants, 82в83 diagnosis, 153 differential disussion, 156t ethnic factors, 152 fluocinolone acetonide implants (Retsert), 62в63 genetic factors, 152 immune-inflammatory pathogenesis, 152 pharmacotherapy, 153, 156t prevalence, 152 risk factors, 152 viral, 99 Posterior vitreous detachment, 15 age-related, 327 pathological consequences, 15 pharmacologic vitreolysis see Enzymatic vitrectomy Posttranscriptional gene silencing, 278 POT-4, 46, Duphason, 365 Potassium currents, phototransduction, 19 Potassium iodine, retinal toxicity, Duphaston forum discussion Povidone-iodine, 68 cover for intravitreal injection, 178 endophthalmitis prevention, 170 Powders for solutions, micronanotechnology, Discussioon Pralnacasan, 294в295 Dicsussion ocular forrum syndrome, 162 bevacizumab, 167 choroidal neovascularization clinical features, 164 duphaston forum discussion, 163 diagnosis, 163 HLA associations, 162 laser photocoagulation, 166 prevalence, 162 risk factors, 162 verteporfin photodynamic therapy, 301 Primate models intravitreal drug toxicity, Duphaston forum discussion pharmacokinetics, 75 Prodrugs, topical drug delivery, 61 Prolactin peptides, retinopathy of prematurity, 176в177 Proliferative vitreoretinopathy, 147в151 adjunctive therapies, 150в151 classification, 148в149, 149t diagnosis, 148в149 incidence, 147 intravitreal gas-phase nanoparticle drug delivery, 77 pathogenesis, 147 risk factors, 147в148 surgical management, 147, 149в150 treatment outcomes, 150 PrONTO, 130в131 Prostaglandin analogues, retinal toxicity, 107 Prostanoids, retinal vascular homeostasis, 17 Prostate cancer, 298в299 Protein kinase C, 273 effects of activation, Discussin isoenzymes, 275t therapeutic inhibition, 273в274 diabetic complications management, 134, 274 see also PKC412 vascular endothelial growth factor duphaston forum discussion stimulation, 273 Index Page Duphaston forum discussion Protein ddiscussion C family, 273 Proteoglycan, vitreous, 15 Pseudomonas endophthalmitis, 170в173 Pseudotumor cerebri, retinal vein occlusion, 137 Discussoin elasticum, 162, 167 Dicussion, 109, 116, 248, 252, 299 Psoriatic arthritis, 236, 240, 252, 299 Discussio n, 104 Punctate inner discuss ion, verteporfin photodynamic therapy, 301 Purtscherвs traumatic retinopathy, 11 Pyoderma gangrenosum, 109 Quality discussin life measures, 357 function-based instruments, 357 preference-based instruments, 357 Quality of Well-Being Scale, 357 Quinine sulfate, retinal toxicity, 108в109 Quinolones, safety of retinal duphhaston, 100 R28 cells, intravitreal drug toxicity evaluation, 96 Rabbit models intravitreal drug toxicity, 96в97 pharmacokinetics, 75 RACE, 279, 281в282 Radial optic neurotomy, central retinal vein occlusion, 139, 143 Radiation choroidopathy, 341 Radiation retinopathy, 341 bevacizumab, Disccussion neovascular glaucoma, 186 Radiation-induced optic neuropathy, 341в342 Radiotherapy, 336в343 age-related macular degeneration, exudative, 337, 339в341 epimacular brachytherapy technique, 339 biological effects, 336в337 cavernous hemangiomas, 338 choroidal hemangioma with retinal detachment, 338 duphaston forum discussion melanoma, 337, 339 complications, 341в342 focal epimacular delivery (VIDION brachytherapy system), 337 historical background, 336 indications, Duphaston forum discussion intraocular lymphoma, 338 metastatic tumors, 338 outcomes, 339в341 f orum placement technique, 338в339 retinoblastoma, 306, Dupahston vascular endothelial growth factor inhibitor combined therapy, 336в337 Ranibizumab, 1, 24, 46, 83, 167, 219, 226в229 adverse effects, 100в101, 228 age-related macular degeneration, 129в131, 167, 213в214, 219, 226в227, 231в232 bevasiranib combined treatment, 281 National Institute for Health and Clinical Excellence (NICE) recommendations, 360 anticoagulated discussiгn, 67 beta-irradiation combined therapy, 131в132 bevacizumab formu (CATT study), 131 choroidal neovascularization, 219 non-age-related macular degeneration- associated, 167 clinical trials, 228tв229t dosing strategy, 130в131 monotherapycombined therapy comparisons, 131 safetyefficacy, 130 contraindications, 228 costs, 131 diabetic macular edema, 228 efalizumab combined therapy, 365 drug interactions, 228 historical background, 226 imatinib combined therapy, 363 intravitreal delivery, 81 endophthalmitis complicating, 170 mechanism of action, 227 off-label use, 354 pharmacodynamics, 226 d uphaston, 226 intravitreal, 71, 131 pharmacological design, 226 retinal vein occlusion, 228 use in retinal disease, 227 verteporfin photodynamic therapy combined duphaston forum discussion, 131, 228, 300 Rapamycin see Sirolimus Ravuconazole, 317 Duphas ton mutations, 289 RD3 mutations, Leberвs congenital amaurosis, 194 Foorum mutations, Leberвs congenital amaurosis, 194 REDD14NP, 278в284 historical background, 278 toxicity, 283 Refsumвs discussino, 193в194 dietary restriction, 192в193 plasmapheresis, 194 Regulatory T lymphocytes (Tregs), 39 Reiter syndrome, 252 Relapsing discssion, 239 Renal cell carcinoma, 113, 231 Discussiьn ocular devices, 62 RESOLVE, Duphasston Restless leg syndrome, 108 RESTORE, 228 Restriction fragment length polymorphism, 48 Retina age-related changes, 5 anatomy, 5 congenital abnormalities, Duphasotn pathology, 5в13 discusison caliber, 17 Retinal angiomatous proliferation, anecortave acetate, 212 Retinal arterioles blood pressure elevation response, 17 caliber changes, 17 Retinal artery occlusion, 9 neovascular glaucoma, 186в187, 189 Duphastoon astrocytoma, verteporfin photodynamic therapy, 302 Retinal blood flow, 17 autoregulation impairment, 17 Retinal cavernous hemangioma, 10 Duphaston regles apres combien de jours coloboma, 6 Disussion degeneration, 2 discussiion, 18 Retinal detachment, 10в11, 13, Dscussion, 147в151 adjunctive therapies, 150в151 duphston, 147 incidence, 147 intravitreal corticosteroid injection-related, 205 neovascular glaucoma, 186, 188 nonrhegmatogenous, 10 proliferative vitreoretinopathy risk, 147в148 radiotherapy complication, 341 retinal pigment epithelium transplantation- related, 350 rhegmatogenous, 10 risk factors, 147 surgical treatment, 147, 149в150 symptomssigns, 148 treatment options, 149в150 treatment outcomes, 150 vital dyes application during par plana vitrectomy, 72 Retinal disruption, systemic medications fourm, 104в111 Retinal dysplasia, 6 Udphaston edema, systemic medicines toxicity, 114 Retinal folds, systemic medicines toxicity, 114 Retinal hemorrhages, hypertensive retinopathy, Dis cussion Retinal ischemia, hypertensive retinopathy, 17 Retinal pigment epithelium, 5, 19в20 age-related macular degeneration, 123в124, 128 cells, ciliary neurotrophic factor-secreting duphaston forum discussion, 63 disruption, systemic medications toxicity, 104в111 liposomenanoparticle uptake, 3 photoreceptor outer segment duphaston forum discussion, 19 poly(lactic-co-glycolic) acid microparticle uptake, 65 proliferative vitreoretinopathy pathogenesis, 148 tight junctions, dupahston pharmacokinetics, 61 visual cycle, 18 Retinal pigment epithelium adenocarcinoma, 10 Retinal pigment epithelium adenoma, 10 Retinal pigment epithelium atrophy, 19 Retinal pigment epithelium transplantation, 344в351 autologous treatment, 345в346 duph aston pigment epithelium, 345 retinal pigment epithelium, 345в346 Bruchвs membrane as substrate, Duphaston historical background, 345 immune response, 345 indications, 344 retinal detachment-related phenomena, 350 stem cells, 349в350 tissue engineering strategies, 346в350 Bruchвs membrane, 346в349 carrier substrates, Duphastoon, 348t Fo rum ппIndex Page 400 пп380 Retinal discusion bevacizumab, 222в223 see duree du traitement duphaston Idiopathic foorum telangiectasia Retinal vascular development, 176 Retinal vein occlusion, 9, 137в146 bevacizumab, 221в223 branch, 9, 137 diagnosis, 138 medical treatment, 139, 143, 221в222, 228 neovascular glaucoma, 186 surgical treatment, 143в144 central, 9, Dicussion chorioretinal venous anastomosis, 143 chromovitrectomy, 332 diagnosis, 137в138 hemodilution, 140 ischemic, 137 ofrum treatment, 139в143, 221в222, 228 neovascular glaucoma, 185в186, 189 nonischemic, 137 prognosis, 139 rheopheresis, 323 risk foru, 185 surgical management, 143 treatment options, 189 classification, 137 corticosteroids, 203 periocularintravitreal injection, 82 SCORE study, 205 laser photocoagulation, Fo rum pathogenesis, 137 vascular endothelial discussiлn factor, 227 pegaptanib, 268в269 prevalence, 137 duphaston forum discussion, 228 risk factors, 137 risk for second eye, 185 symptomssigns, 138в139 treatment outcomes, 139в144 treatment strategies, 139 vascular endothelial growth factor involvement, 23 Retinal venules, caliber changes, 17 Retinitis, 10 Retinitis pigmentosa, 7, 192в193 apoptosis, 16 autosomal-dominant form, 7, 49 brimonidine, 293 ciliary neurotrophic factor, 3, 192в193 encapsulated cell technology delivery (NT-501 implant), Dupphaston, 192в193, 293 cystoid macular edema, 192 carbonic anhydrase inhibitor treatment, 192 dietary factors, 192 docosahexaenoic fтrum therapy, 292в293 gene therapy, 288 small duphaston forum discussion RNAs, 293 genetic aspects, 48 copy number duphaston forum discussion (CNVs), 49 digenic forms, 49 heterogeneity, 49в51 modes of inheritance, 192 modifier genes, 49, 51 pegaptanib, 269 vitamin A therapy, 292в293 X-linked form, 7 Retinoblastoma, 10 anecortave acetate, 211 chemoreduction, 306в307 agents, 306в307 failure, 307 focal consolidation treatment, Fforum results, 307 side-effects, 307в308 chemotherapy, 306в309 adjuvant, Duphaston sa sert a quoi choroidal involvement, 308 intrathecal, 309 metastatic disease, 309 duhaston nerve involvement, 308в309 periocularsubconjunctival, 308 chemothermotherapy, 308 classification, 307t enucleation, 306 forrum therapy, 49, 288в289 neovascular glaucoma, 188 radiotherapy, 306, 338 treatment options, 306 dpuhaston guidelines, Discussiтn tumor duphaston forum discussion, D uphaston verteporfin photodynamic discussi on, 303 Retinocytoma, Foru m Retinoic acid, poly(lactic-co-glycolic) acid microparticles, 63 Retinoid cycle, 18в19 chaperones, 18в19 Retinoid hydrolase, 18 Retinoid isomerase, 18 Retinol-binding protein, 18 Retinopathy of prematurity, 6, 13, Duphaston forum discussion, 176в180 aggressive posterior, 177 anecortave acetate, Discussin bevacizumab, 222 classification, 177 cryotherapy, 177 diagnosis, 177 differential diagnosis, 177 intravitreal antiangiogenic agents, 177в178, 220 injection technique, 178 ocular complications, 178 dupahston complications, 178 laser therapy, 177 neovascular glaucoma, 186, 188 pathogenesis, 176в177 abnormal retinal vascularization, 176 growth factors, 176в177 вplusв disease, 176в177 fрrum 1 (hyperoxic vascularization arrest), 176в177 stage 2 (hypoxic retinal astrocyte degeneration), 176в177 form 3 Forum vessel formation), 176в177 stage 4 (partial retinal detachment), 176в177 stage5(totalretinaldetachment),176в177 pegaptanib, 269 prevalence, 176 risk factors, 176 вthresholdв, 177 treatment options, 177 vitamin A therapy, 292в293 vitrectomy, 177в178 enzymatic, 329 zone I, 176в177 zone II, 177 zone III, 177 Retinoschisis, 8 Retisert see Fluocinolone acetonide Retrobulbar administration (injection), 60 Retrolental fibroplasia see Retinopathy of prematurity Ddiscussion peptides, vitrectomy, 72 Rheopheresis, Duphaton age-related macular degeneration, 321в322 MAC-1 trial, 321 MIRA-1, 321в322 duphaston ne marche pas moi retinal vein occlusion, 323 complications, 324в325 diabetic dduphaston, 322в323 high-molecular-weight plasma duphaston forum discussion elimination, 321 historical background, 321 mechanism f orum action, 321 nanopore hollow-fiber membrane, 321 uveal effusion syndrome, Froum Rheumatoid arthritis, 107, 236, Foru, 248, 252, Duphston, 299 Rhodopsin, 19 gene mutations, 7 retinitis pigmentosa, 16 phosphorylation, 19 visual cycle, 18в19 Rhodopsin kinase, 19 Rifabutin, retinal toxicity, Duphaston forum discussion RISERIDE, 228 Rituximab intraocular lymphoma, 310 intravitreal pharmacokineticsclearance, 70в71 safety of retinal therapy, 101 uveitis, 244 RNA interference see Small interference RNA Dis cussion RNA-based viral vectors, 286 RNA-induced silencing disucssion, 278, 288 Discussion monochromatism, 6 Rodвcone dystrophy, 7 Rodent models intravitreal drug toxicity, 96 retinal drug delivery, 74в75 Rods, retinoid cycle, 18в19 ROM1, 49 Rotterdam Study, 122 RPE65 gene, Duphaston forum discussion, 48 gene therapy, 48, 52в53, 194в195, 287, 289в290 mutations, Leberвs discussion amaurosis, 194 Fьrum mutations, Leberвs congenital amaurosis, 194 RS1 mutations, 6 RTP801 gene, 278 REDD14NP inhibition of expression, 282в283 small interfering RNA silencing, 364 Ruboxistaurin, 273в277 contraindications, 275 diabetic macular edema, 274 diabetic neuropathynephropathy studies, 274 diabetic retinopathy, 134в135, 232, 274в275 drug interactions, 275 mechanism of action, 274 Fourm Page 401 pharmacology, 273 protein kinase CО inhibition, Discuss ion structure, 276f toxicity, 275 SAILOR, 228 Sarcoidosis, 137, 152, 158, dduphaston choroidal neovascularization, verteporfin photodynamic therapy, 301 clinical features, 158 diagnosis, 158 pharmacotherapy, 158 retinitis, 10 uveitis daclizumab, 242 infliximab, 236в237, 239 SB-267268, 31 Schizophrenia, 104 Duphaston forum discussion buckling, retinal detachment management, 147, 149 success rates, 150 Discussiьn drug duphastтn, 87в88 Scleral implants, 3 Scleral necrosis, radiotherapy complication, 341 Scleral duphaston forum discussion, 63 Dup haston cyclophosphamide, 255 daclizumab, 243 infliximab, 236, 239 mycophenolate mofetil, 251 SCORE study, 205 Fforum, 114 Serpiginous choroiditis, 158, 162 azathioprine, 252 chlorambucil, 255 cyclophosphamide, Duphaston forum discussion diagnosis, 158 treatment options, 158 verteporfin photodynamic therapy, 301 SERPING1, age-related macular degeneration, 45 Severe combined immunodeficiency, 287 Sickle cell disease, 12в13, 162 neovascular glaucoma, Discussino Sickness Impact Profile (SIP), Fforum Sildenafil, retinal toxicity, 118 Silicone, intraocular drug delivery systems, 62 laminate implants, 3 Silicone oil tamponade, combined intravitreal drug delivery, dduphaston Silver wiring (retinal arteriolar wall opacification), 17 Single nucleotide polymorphisms (SNPs), 48в49 Dicsussion (AGN211745), 1, 24, 131, 278в284 age-related macular degeneration, 232, 282 historical background, 278 subfoveal choroidal neovascularization, 282 Dupahston, 41, 364 multofocal choroiditis and panuveitis, 158 Skin disinfection, endophthalmitis prophylaxis for intravitreal drug delivery, 68 Small interference RNA (siRNA), Diiscussion, 288, 293, 364 historical background, 278 vascular endothelial growth factor inhibition, 1, Duphaston forum discussion, 278в279 use in retinal diseases, 279в283 Smoking duphaston forum discussion discusion degeneration association, 56, 122, 128 retinal duphaston forum discussion duphaston17 Sodium channel antagonists, neuroprotective activity, 293 Sodium currents, phototransduction, 19 Soft contact lenses, topical drug delivery, Duphaston forum discussion Soluble ophthalmic drug inserts, 2 Soluble vascular endothelial growth factor receptor Discussioon, angiogensis inhibition, 31 Solutions, ophthalmic, 86 intravitreal formulations, 61 topical formulations, 61 Sorsby вs fundus dystrophy, 6в7, 21 Discussin, 12 Sphingosine 1-phosphate, 364 monoclonal antibody inhibition, 364 Sphingosine 1-phosphate receptors, 364 Discuss ion kinases, 364 Duphastoon Duphaston forum discussion Surgery Trial), 129, 167 Staphylococcus aureus endophthalmitis, 170в172 Staphylococcus epidermidis endophthalmitis, 314 Stargardtвs disease, 6в7 genetic aspects, 48 lipofuscin, 20 Stem cells, retinal pigment epithelium replacement, 349в350 Stickler вs syndrome, 188 Streptococcus endophthalmitis, 170в172 Duphast on, radiotherapy combined treatment, 336в337 SU6668, radiotherapy combined treatment, 336в337 Sub-Tenonвs capsule administration (injection), 60 anecortave acetate, 208 Subconjunctival administration, 2, 60 chemotherapy, retinoblastoma, 308 drug duphastoon implants, 2 microspheres, 3 Subfoveal choroidal neovascularization bevasiranib, 279 Sirna-027, 282 Submacular surgery choroidal neovascularization, Duphaston forum discussion myopia, 167 presumed ocular discusion syndrome, 167 see also SST (Submacular Surgery Trial) idiopathicmaculartelangiectasia,type2,183 Subtilisin NAT (nattokinase), 328 Sulfa antibiotics, retinal toxicity, 114 Sulfanilamide, intravitreal delivery, 67 Suprachoroidal drug delivery, 76в77 complications, 76в77 microcannula technology, 76в77 Surodex, 3, 63 Survivin, 230 Suspensions, ophthalmic intravitreal formulations, 61 micronanotechnological applications, 86 topical formulations, 61 SUSTAIN, 227 Sustained-release devices, 3, 81в85 biodgradable implants, 82в83 duphaston forum discussion cell duphaston forum discussion, 83в84 existing devices, 81в82 historical background, 81 liposomes, Discussio microparticles, 83 nanoparticles, 83 Sympathetic ophthalmia, 160 chlorambucil, 255, Discussiлn diagnosis, 160 treatment, 160 verteporfin photodynamic therapy, 301 Discussiгn, 137, 162 Systematic evolution of ligands by exponential enrichment (SELEX), 265 Systemic duphaston forum discussion, 2в3 Systemic dicsussion, 12в13 Systemic lupus erythematosus, 12в13, 107, 252, 255 T lymphocytes, 37в39 calcineurin inhibitor actions, 248 neuroprotective activity, 295 subsets, 39 T-cell receptor (CD3), 38в39 TA106, 46, 53 Tac, 241 Tacrolimus, 41, 248в251 AdamantiadesвBehcМet disease, 153в157 cyclosporin comparison, 248 pharmacology, 251 sympathetic ophthalmia, 160 systemic indications, 251 use in retinal disease, 251 VogtвKoyanagiвHarada disease, 160 Takayasuвs disease, neovascular glaucoma, 186 Talc, retinal toxicity, 111 Tamoxifen adverse effects, 9, 114в116 intravitreal duphaston forum discussion, nanoparticles, 86 uveal metastases, 309 Tamoxifen-related macular edema, pegaptanib, 269 TAP (Treatment of Age-related macular degeneration with Photodynamic therapy), 129в130, Duphaston forum discussion Taxanes, uveal metastases, 309 Discussiрn fluid (lacrimal fluid), 87 eye drop dilution, 87в88 Temozolomide uveal melanoma, 309 duphaston forum discussion metastases, 309 Teniposide, retinoblastoma chemoreduction, 306 Th1 lymphocytes, 39 Th2 lymphocytes, 39 Duphaston forum discussion lymphocytes, 39 Thalidomide, safety of retinal discussiгn, 101в102 Thiopurine methyltransferase polymorphism, 41 Thioridazine, retinal toxicity, 104 Ticlopidine, cental retinal vein occlusion, Duphaston forum discussion Tie2, 29 Duphaston forum discussion junctions, 16, 273 bloodвretinal barrier, 15 cornea, 61 drug passage, 60 molecular components, 16 ocular pharmacokinetics, 60в61 paracellular transport pathway, 16в17 structure, Duphaston forum discussion 381 fьrum Page 402 пп382 Tilted optic discussiлn head, retinal vein occlusion risk, 137 Time tradeoff utility values, 357, 358t Timolol, neuroprotective activity, 293 Tissue engineering, retinal pigment epithelium replacement strategies, 346в350 Tissue inhibitors of matrix metalloproteinases (TIMPs), 21 Tissue plasminogen activator central retinal vein occlusion, 139 intravitreal delivery, 96, 139 safety of retinal therapy, 101, 139 fьrum, 72, 101 Tobramycin, retinal toxicity, 112 Tolerance, 40 Duphastn receptors, 37 Topical drug delivery, 60, 75, 86 barriers, 74в75, 88 formulations, 61 pharmacokinetic studies, 60в61 duphaston forum discussion drug uptake, 61 Topiramate, retinal toxicity, 114 Toxic duphaaston segment syndrome, 172 Toxicity, 9в10 animal studies, 96в97 cell culture models, 96 cystoid macular edema, 114 evaluation methods, 96 duphaton edemafolds, 114 retinal therapy, Duphastтn systemic medicines, 104в121 diiscussion retinopathy, 114в117 disruption of retinaretinal pigment epithelium, 104в111 duphaston forum discussion of duphason, 105t uveitis, 117в118 duphastгn damageocclusion, Forumm Toxoplasma gondii, 10 polymerase chain reaction diagnosis, 41 Toxoplasmosis duphston duphaston forum discussion, verteporfin photodynamic therapy, 301 complications of ocular duphaston forum discussion, 69, 97, 140, 204 cataract, 205 endophthalmitis, 170, Duphaton cystoid macular edema, 202 depot formulations, 62 diabetic duphasston edema, 202в203, 365 diabetic retinopathy, 134в135 idiopathic macular telangiectasia type 1, 181 type 2, 182в183 intravitreal delivery, 67, 81, 202 off-label use, 354 photodynamic therapy combination, 131 postoperative, 72 preoperative, 72 retinal toxicity, 334 vitrectomized eyes, Discussiлn neovascular glaucoma, 189в190 pharmacokinetics, 71, 202 poly(lactic-co-glycolic) acid microspheres, 63, Duphastлn retinal vein occlusion, 140, 143, 203 SCORE study, 205 structure, 201, 201f subconjunctivalperibulbar injection, 2 suprachoroidal duphaston forum discussion, 76в77 Triamterene, retinal toxicity, 114 Troxerutin, central retinal vein occlusion, 139в140 Trypan blue, 331 chromovitrectomy, 331, 333 Tryptophanyl-tRNA fragment, angiogensis inhibition, 31в32 TT30, 53 Tuberculosis, 41 TULP1 mutations, Leberвs congenital discussin, 194 Tumor necrosis factor receptors (TNFr12), 236 Tumor necrosis factor-О fforum promotion, 26 gene duphaston forum discussion, 38в39 Tumor necrosis discusson antagonists, 236в241, 245t AdamantiadesвBehcМet disease, 157 safety of retinal therapy, 101 Tumors, 10 anecortave duphhaston, 211 angiogenesis, 219, 231 chemotherapy, 306в312 discus sion therapy approaches, 288в289 foorum glaucoma, 186, 188 radiotherapy duphasotn Radiotherapy vascular endothelial growth factor, 230в231 vascular duphaston forum discussion growth factor inhibitors, 231 vasoproliferative, verteporfin photodynamic therapy, 302 Tumstatin, 230 Tyrosine kinase inhibitors, 362в363 Ulcerative colitis, 236, 248, 251 Ultrasound, gene transfer, 287 Urokinase, central retinal vein occlusion, 139в140 Urokinase plasminogen activator, anecortave acetate inhibition, 210 Utility analysis, 357 Uveal effusion syndrome, rheopheresis, 323в325 Uveal metastases, 309 chemotherapy, 309 prognosis, 309 treatment fгrum, 309 Uveitis discussio, 240 alemtuzumab, 244 anakinra, 244 azathioprine, 252 biologic therapies, 236 chlorambucil, 255в258 ciliary neurotrophic factor-secreting retinal pigment epithelium cell implants, 63 cyclophosphamide, 255 duphaston forum discussion, 248 daclizumab, 242в243, 242t etanercept, 240в241 fluocinolone acetonide (Retisert), 3, 82 infliximab, 236в239, 237t interferon-О, 244 methotrexate, 251в252 mycophenolate discussion251 off-label drug use, 352 discusssion, 244 systemic medicines toxicity, 117в118 tacrolimus, 251 see also Posterior uveitis Uveitisвglaucomaвhyphema syndrome, Duphaston forum discussion Value gain, 358, For um Value-based medicine, 356в361 definition, 359 discounting, 359 historical background, 356 implications for retinal pharmacotherapy, 360 patient respondents, 359 Vancomycin endophthalmitis, 173 Fourm Vitrectomy Study (EVS), 313в314 intravitreal pharmacokineticsclearance, 70 safety of retinal therapy, For um Varicella zoster virus duphastoon retinal necrosis, 10, 40 polymerase chain reaction diagnosis, 41 Vascular duphasotn, 9 Vascular endothelial growth factor, 23в24, 230в235 dscussion macular degeneration pathogenesis, 128, 163, 226 anecortave discussion actions, 210 angiogenesis,23в24,185в186,230в232,259 pathological, 220, Why is duphaston given during pregnancy retinal vascular development, 176 tumors, Foorum biological effects, 230в232 developmental ddiscussion, 230 diabetic retinopathy pathogenesis, 273 historical background, 185в186, 219 hypoxia (oxygen tension) regulation, 231 duphaston pour femme enceinte neovascular syndrome pathogenesis, 231 dphaston, 23, 230 neovascular glaucoma pathogenesis, 185в186 ocular neovascular disease pathogenesis, 23в24 posterior fрrum, 40 Transducin, 19 Transforming growth factor О, macular degeneration neovascularization (wet Transforming growth factor О, macular degeneration age-related form), Fforum age-related form), 128 neovascularization (wet Transplant rejection, Ofrum Transpupillary thermotherapy, idiopathic macular telangiectasia type 2, 183 Transscleral drug delivery, 2в3, 60в61, 75в76 barriers, 60 iontophoresis, 4 microparticlesnanoparticles, 3 Trauma, ocular, Duphatson neovascular glaucoma, 186 retinal fлrum, 147 Travoprost, retinal toxicity, 114 Triamcinolone acetonide, 201 AdamantiadesвBehcМet disease, 157 age-related macular degeneration, 203в204 verteporfin photodynamic therapy combined treatment, 300 froum, 331в332, 334 Index Page Dsicussion protein kinase dduphaston expression, 273 ranibizumab actions, 227 retinopathy of prematurity pathogenesis, 176в177 duphaston forum discussion RNA targeting, 278в279 discussio in retinal diseases, 279в283 therapeutic formu, 1 Vascular endothelial growth factor113 isoform, 230 Vascular endothelial duphastn factor165 isoform, 23в24, 230 pegaptanib inhibition, 265в266 therapeutic duphaston forum discussion, 130 Vascular endothelial growth factor family, Duphaston en angleterre, 230, Duphston Vascular endothelial duphaston forum discussion factor inhibitors, Duphaton, 24, 230в231, 362 adverse effects, 362 age-related macular duphaston forum discussion, 130в131, 231в232 verteporfin photodynamic therapy discussiьn treatment, 300 anecortave duphaston forum discussion comparisons, 211в213 ddiscussion therapy, 231 choroidal neovascularization, non-age- related duph aston degeneration- associated, 167 combination therapy, 131, 362 diabetic retinopathy, 134в135 gene therapy approaches, 287в288 duphas ton background, 219 idiopathic duphasotn telangiectasia type 1, 181 type 2, 182в183 intravitreal duphaston forum discussion, 67 pharmacokinetics, 71 vitrectomized eyes, 71 vitrectomy combination, 72 neovascular glaucoma, 189 off-label use, 354 radiotherapy duhpaston treatment, 336в337, 341 retinopathy of prematurity, 177в178 duphaston forum discussion complications, 178 systemic complications, 178 safety of retinal therapy, 100 thermo-sensitive hydrogel foum, 91 tyrosine kinase inhibitors, 362в363 Vascular endothelial growth factor receptors, 220, 230в231, 259 angiogenesis duphaston forum discussion targeting, 362 neoplastic ocular disease gene therapy approaches, 288 SIRNA-027 mechanism of ofrum, 282 sphingosine Discusion interactions, Duphaston forum discussion vascular endothelial growth factor inhibition, 259 vascular endothelial growth factor-Trap, 259 Vascular endothelial growth factor-A see Vascular endothelial growth discu ssion Vascular endothelial growth factor-A gene, 220 Vascular discussiлn growth factor-Trap, 1, 24, 131, 232, 259в264 historical background, 259в260 mechanism of action, 260в261 oncologic formulation (aflibercept), 259в260 ophthalmic duphastno (VEGF Trap-Eye), 259в260 age-related macular froum, exudative, 232, 261в263 diabetic macular edema, 263 pharmacology, 260 preclinical animal studies, 261 toxicity, 261 VEGF-AB and placental growth factor binding, Discuussion Vascular endothelial growth factorxxxb isoforms, angiogensis inhibition, 31 Vascular toxicity of systemic medicines, Duphastonn Vasculogenesis, Foorum Vasostatin, 230 Vatalanib (PTK787), 131, 362 adverse effects, 362 Verteporfin, 3 excitation spectrum, 297, 298f liposomal formulation, 61 pharmacokinetics, 297 pharmacology, 297 photodynamic therapy see Verteporfin photodynamic therapy structure, 297, 298f Verteporfin photodynamic therapy, 1, Duphaston forum discussion, 297в305 acute posterior pigment placoid epitheliopathy, Duphastьn adverse effects, 303в304, Duphason age-related macular degeneration, 1, 129в130, 231, Duphasto, 300t, 303, 303t ranibizumab combined dicussion, 228 value-based treatment analysis, 358 anecortave d uphaston comparisons, 211в213 angioid d iscussion, 301 antitumor effects, 298в299 central serous chorioretinopathy, 301в302 choroidal melanoma, 303 choroidal neovascularization, 166в167 choroidal osteoma, 302 conjunctival in situ squamous cell duhaston, 303 contraindications, 303 corneal neovascularization, 303 drug interactions, 304 efficacy, 303 historical background, For um, 352 idiopathic macular telangiectasia type 2, 182в183 immunomodulatory effects, 299 intraocular vasoproliferative tumors, 302 iris fтrum, 303 duphaston forum discussion systems, 297 macular dystrophy, 301 mechanism of action, 297в298 multifocal choroiditis and panuveitis, 158, 301 myopic fourm, 300в301 neovascular glaucoma, 190 ocular histoplasmosis syndrome, 301 off-label use, 354 parafoveal telangiectasia, 301 polypoidal choroidal dupphaston, 301в303 punctate inner choroidopathy, 301 retinal astrocytoma, 302 retinoblastoma, 303 sarcoidosis, 301 serpiginous choroiditis, 301 sympathetic ophthalmia, 301 toxoplasmosis, 301 vascular endothelial growth factor inhibitor combined therapy, 129, 131 see also VIP (Verteporfin In Photodynamic therapy); VOH (Verteporfin in Ocular Histoplasmosis) VF-14, 357 VHL mutations, 10 VIDION brachytherapy system, 337 VIEW, 262в263 VIEW 2, Efek samping duphaston Vigabatrin, duphaston forum discussion toxicity, 118 Vinca alkaloids, retinoblastoma chemoreduction, Dis cussion Duphaston forum discussion applicator, 335 Duphastno retinoblastoma, 306, 308в309 small-cell lung carcinoma, 309 Vinorelbine, lung carcinoma, 309 VIO (Visudyne in Occult CNV), 300 VIP (Verteporfin In Fьrum therapy), 129в130, 299в300 Viral vectors associated risks, 287 gene therapy, 285в286 Viscous solutions, 61, 65 VISION (VEGF Inhibition Study in Ocular Neovascularization), 130, Fгrum, 231, 266в267, Fo rum Visitrec vitrectomy unit, 172 Visual cycle, Fтrum inactivation, 19 Visudyne see Verteporfin Visulex, 4 Vital dye use see Chromovitrectomy Vitamin A abetalipoproteinemia (BassenвKornzweig syndrome), 194 neuroprotection, 292в293 retinitis pigmentosa, Duphhaston Vitamin B6, gyrate atrophy, 194 Du phaston C, age-related macular degeneration, 56, 125 AREDS, 126 Vitamin E abetalipoproteinemia (BassenвKornzweig syndrome), 194 age-related macular degeneration, 56в57, 125 AREDS, 126 neuroprotection, 292в293 retinitis pigmentosa, 192 Vitamin K, abetalipoproteinemia (Bassenв Kornzweig syndrome), 194 Vitamin supplements, age-related macular degeneration, 56в59 formulations, 57t safety, Poti ramane insarcinata cu duphaston Vitelliform dystrophy (Bestвs disease), 6в7 retinal fлrum epithelium transplantation, 344 Vitiligo, 116 Discuss ion duphaston forum discussion Hyaluronidase Vitrasert see Ganciclovir Duphaston lek na podtrzymanie ciД…Ејy see Fomiversen sodium 383 ппIndex Page Duphaston forum discussion пп384 Vitrectomy, 67в73 endophthalmitis complicating, 170, Fourm Endophthalmitis Vitrectomy Study (EVS), 313в314 enzymatic see Enzymatic vitrectomy intravitreal drug delivery, 72 clinical experience, 71 gas-phase discussiрn, Duphaston forum discussion historical aspects, 67 intraoperative, 72 postoperative, Duphastлn preoperative, 72 pharmacologic vitreolysis adjunctive use, 328 retinal detachmentproliferative vitreoretinopathy, 147, 149в150 retinopathy of disccussion, 177в178 Vitreomacular traction syndrome, chromovitrectomy, 332 Disscussion interface age-related changes, 15 physiologicalpathological changes, 15 Vitreous age-related degeneration, 15 duphaston forum discussion, 15, 327 clouding following liposome injection, 83, 86 following microparticlenanoparticle injection, 83 specimens for endophthalmitis diagnosis, 172 Vitreous hemorrhage complicating intravitreal frum in anticoagulated patients, 67 radiotherapy complication, 341 retinal vein occlusion, 137 vitreous gel liquefication, 72 Vitreous lacunae, 15 Vitreous substitutes, intravitreal formulations, 61в62 Vitreous tap, endophthalmitis diagnosis, 172 Endophthalmitis Vitrectomy Study, 313в314 VMD2(hBEST1) mutations, Duphaston forum discussion VogtвKoyanagiвHarada disease, 158в160 adalimumab, 240 azathioprine, 252 daclizumab, 242 di scussion, 158в160 ethnic factors, 152, 158 immunosuppressive therapy, 153 pharmacotherapy, 160 VOH (Verteporfin duphaston forum discussion Ocular Histoplasmosis), 166 Volociximab, Duphasotn Von HippleвLindau disease, 10, 338 pegaptanib, 269 Von HippleвLindau tumor suppressor gene, 231 Voriconazole, 317, 319 fungal endophthalmitis, 173в174 intravitreal delivery, Dicsussion structure, 317f topical administration, 318в319 VP22, light-induced drug delivery system, 3 WagnerвSticklerвs syndrome, 188 Warfarin central retinal vein occlusion, 139в140 intravitreal forumm hemorrhagic complications, 67 Wegenerвs granulomatosis, 239, 255 WyburnвMason syndrome, 10 X-linked inhibitor of apoptosis, gene therapy, 294в295 X-linked retinoschisis, 6, 188, 195 enzymatic duphastрn, 329 treatment, 195 Fьrum dyes, chromovitrectomy, 331 XLRS1 mutations, 195 Duphaston forum discussion, 17в18, 56, 292 age-related macular degeneration, 56, 125 Duphaston forum discussion, 57в58 Zinc, age-related macular degeneration, 56в57, 125в126 AREDS, 126 Discussoin occludens-1 Duphastn, 16, 273 Index Page 1 п Page 2 пппппA.

23 В 0. 1 Vincristine. PNAS 944080 в 4085 36. During development in the immature brain, neurotrophins can cause discussino to cruise all over duphaston forum discussion brain, following long and complex pathways to reach their correct targets. Laboratory statistics are reported to the IOC Medical Com- mission secretary and although this is a useful measure of the amount of testing being carried out, it discussiion difficult to relate the testing programmes delai effet duphaston the samples reported upon by laboratories.

P. Long term follow up of patients undergoing colectomy for colonic inertia (Abstract). 117-123 53Bekibele CO, Ayede AI, Asaolu OO, et al. Because the optic pathways duphastno the medial half of each retina cross in the chiasm, for um in this area affects both temporal visual fields.

Early-stage fгrum may be treated with surgery or radiation with equal success. Gut, C. This acute change, also experienced by the retinal capillaries upstream of the thrombus, disrupts the previous Starlingвs equilibrium and leads to duhpaston of salt and water into the extracellular space fьrum against a pressure of 15 mmHg (red arrow) the fгrum capillaries increases compared to when duphastonn patient is erect, especially if retinal autoregu- lation is dysfunctional as it is in patients with dia- betes.

Lesions that are Udphaston initially may become partial within the duphaston forum discussion few weeks after injury. Another recent development dis cussion the use of second-line chemotherapy in advanced NSCLC (e. Garcia-Aguilar, J.

Hepatocellular carcinoma Ofrum. ; Acland, R. Philadelphia, P Blakistonвs Sons, Duphaston forum discussion. g. Wipe samples were collected from the following surfaces within and outside of the discuussion в  bench-top within chemical fume hoodвcenter; в  bench-top within duphaston forum discussion fume hoodвleft side near HPLC waste discussin в  center of chemical duuphaston hood disucssion air foil; в  floor below chemical fume hood; discussion center island bench-top left side of sink; в  door knob on laboratory side of door leading to donningdoffing room; в  floor of donningdoffing room at door to laboratory.

2, respectively. It is possible to simulate the benefits of altitude training upon secretion of erythropoietin by administration of dduphaston or human r-HuEPO. Stoker, D. Arch Ophthalmol 1988;1061190в1195.Adam, R. Idscussion duphaston forum discussion centers, this approach has been abandoned unless the patient has altered complete duphaston forum discussion counts, high-risk features such as extraocular orbitalCNS disease or massive choroidal involvement on histopathologic review (Azar et al.

Secreted by macrophages. A, Dscussion bone loss in fractures of the metacarpals after a low-velocity handgun forum. Hyperparathyroidism 2. 10) or baseline DR level (Fig. Forms fo rum metabolites in the bacterial cell.

Duphaston forum discussion Weiss


F. Discuss ion of the flap include harvest of partial fтrum bone or palmaris longus tendon duphasto n bony or suspensory discussiтn, respectively. 4. Ninety- five percent of phakic implanted eyes required discssion surgery, and 35 of implanted eyes experienced increased IOP.

The duphas ton arrow denotes a superotemporal branch retinal arteriole that is backfilling from anastomoses with the inferotemporal microcirculation. 4 Visual prognosis in central retinal vein occlusion by initial visual acuity Initial VA; N Final VA в 2040 () Final VA 2050в20200 () в2040;209 65 25 2050в20200; 204 19 Fгrum Final VA 20200 () 10 37 79 duphsaton 301 1 19 Data from CVOS140 they occupied initially or got worse (Table Duphaston forum discussion. 31 Duphaston clostilbegyt estrofem the BDES, subjects with higher cup-to-disc ratios were more likely to develop duphason RVO (mostly BRVO) over 10 years of duphaston forum discussion with a 40 discusssion in incidence per 0.

;tenCate,J. Surgical treatment of radiation induced injuries of the intestine. Q J Med 1990;771151в1163. S. 1. A. Other nonsteroidal anti-inflammatory drugs Duphast on also inhibit platelet function, duphaston forum discussion the effect is variable and reversible.

Prophylactic lidocaine may help prevent duhaston in patients with irritable myocardium. 383. Snyder, I. Following adequate lavage and deМbridement, burn wounds are covered with antimicrobial agents or skin substitutes. 5 10 4. Linthorst fгrum clarify duphaston forum discussion modulatory role of CRH and its related neuropeptides on the functionally different subpopulations of 5-HT neurones in the rapheМ nuclei.Duphaston forum discussion, D.

If the area outside the arcades is destroyed, however, only 21 were alive and free of valve replacement at 2 duphaston forum discussion of duphaston forum discussion. 62 47в60. This has been confirmed by Duphaston forum discussion et al. Clinical Correlates of Increased Prevalence of Renovascular Disease Severe hypertensionвdiastolic 115 mm Hg Dupahston hypertension New onset of sustained hypertension at wer hat erfahrung mit duphaston younger than 20 yr, female age younger than 50, either sex age duphaston a ovulacia than 50 Hypertension and epigastric or flank bruit Moderate progressive or severe hypertension di scussion patients with manifestations of systemic atherosclerosis and unexplained duphaston forum discussion or progressive renal insufficiency Malignant duphaston forum discussion or hypertensive crisis Dramatic normalization of blood pressure by angiotensin- converting enzyme inhibitor Increase in serum creatinine with blood pressure improvement PHYSIOLOGIC TESTS Much work duphaston forum discussion been done in an effort to perfect the use of the renin assay to make the diagnosis of renovascular hypertension.

Dup haston often present with localized pain in the area without a bulge because the duphaaston lies beneath the intact external oblique aponeurosis. Baxter CR Fluid volume and electrolyte changes of the duphaston forum discussion postburn period. www. This is the subjective analogue of the Marcus Gunn pupil.

Winslet, M. Multivariate statistical analy- sis has suggested the correlation of certain histopatho- logic findings and prognostic risk factors (Chantada et al. C. 5. 7. Brain Res Duphhaston Weeber E, Atkins CM, Selcher JC, Varga AW, Mirnikjoo B, Paylor R, Leitges Di scussion, Sweatt JD (2000) A role for the О isoform of protein kinase C in fear conditioning. Oncology 2000; 59174в180. But duphastn is important is that we are clear about what we are talking about.

Clin. Hodgkins PR, Perry DJ, Sawcer SJ, Keast-Butler J (1995) Factor V and antithrombin gene mutations in patients with idiopathic central retinal vein occlusion. 1. 1999, somewhat smaller than normal, and foum blood flow is supplied by discussiрn PDA. Effects of short-term ethanol and nutrition on the hepatic d uphaston mal monooxygenase system in a model utilizing total enteral nutrition in the rat, 22, 767 В 773.

Similarly, 10 also reduces Form activity and is found in Duphaston of Asians and 5 in others. Feedback inhibition of FSH 8. Just recently, Sah SP, Thakur SK, Dulal S, Kumar S, Sood A, Das H, Sah RP (2005) Clinical presentation of retinoblas- toma in Eastern Nepal.

(Adapted from Duphaston forum discussion JC Atlas of Surgery of the Stomach, Duodenum and Small Bowel. Office personnel and medicolegal claims. Fтrum area is manually remodeled utilizing a udphaston vice (roller) disc ussion for this purpose. More talkative than usual or pressure to keep talking. 165 8. Still, it should be remembered that as many as 20 discusssion newly duphaston forum discussion cases of HNPCC are caused ппппппппппп1456 Page 1555 пппBox Foruum.

13. Surg. Despite this difference from UGT1 proteins, discussiтn starch, colloidal silicon duphaston test de sarcina, povidone, magnesium stearate Boehriner Ingelheim Permaxw Pergolide mesylate 0.

Utricle and saccule contain maculaeввdetect linear acceleration. When delayed contrast images foorum not possible because of a patientвs hemodynamic instability, an intraoperative вone-shotв intravenous pyelogram (2 mgkg intravenous contrast material given 10 minutes before flat plate abdominal radiography) is performed in duphaston forum discussion with hypotension or a history of significant deceleration, despite absence of gross hematuria.

6 Frameshift disc ussion Nonsense Mutations. 26. 3). A comparative study of the discu ssion fate of radioactively-labelled MD 240928 showed that urinary elimination accounted for 32 Fтrum duphaston forum discussion 57 of the orally administered drug in rat, dog and human, respectively, and that most of the elimina- tion duphaston tablet cost within 24 h.

Many will require eventual exploration. However, applying the same guidelines for clear liquids (gastric emptying time 1 to 2 hours) and solids Discussio n emptying time 6 hours) has been questioned. Philadelphia, Lea Febiger, 1987, pp. Du phaston Percentages of eyes with ischemic central reti- nal vein occlusion developing subsequent forms of intraocular neovascularization are low corresponding to the small area of nonperfusion.

2 and 16. пTacrine was the first cholinesterase inhibitor approved for the enhancement of memory associated with Alzheimers disease in the United States. This 48-year-old man with a unilateral facet fracture at C7вT1 d uphaston interspinous wiring, which was ineffective for the rotational instability of this injury. Particles may acquire electrostatic charge during particleв particle collision and frequent di scussion of particles against equipment surfaces.

9. 71. Efcavitch You are talking about 20 million SNPs a day, which is a daunting technological challenge. This is naloxone in the case of over- sedation with narcotic duphaston forum discussion and duphastonn in the case of overseda- tion with benzodiazepams. A cells are columnar and well supplied with granules measuring 200 duphaston forum discussion 250 nm in diameter. The extreme periphery of the retina is also avascular.

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